Literature DB >> 19383307

Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7.

David Lindquist1, Mircea Romanitan, Lalle Hammarstedt, Anders Näsman, Hanna Dahlstrand, Johan Lindholm, Liselotte Onelöv, Torbjörn Ramqvist, Weimin Ye, Eva Munck-Wikland, Tina Dalianis.   

Abstract

From 1970 to 2002 in the Stockholm area, we revealed a parallel three-fold increase in the incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases, indicating a possible role of HPV infection in this disease. We have now examined whether HPV and viral load in pre-treatment tonsillar cancer biopsies correlates to disease prognosis, and whether the presence of HPV-16 E6 and E7 mRNA could be ascertained. The presence of HPV-16, but not viral load, in tonsillar cancer was shown to be a favourable prognostic factor for clinical outcome. Moreover, E6 and/or E7 were expressed in almost all assessable HPV-16 positive cases, supporting an oncogenic role of HPV-16 in tonsillar cancer.

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Year:  2007        PMID： 19383307      PMCID： PMC5543872          DOI： 10.1016/j.molonc.2007.08.005

Source DB:  PubMed          Journal:  Mol Oncol        ISSN： 1574-7891            Impact factor:   6.603


  28 in total

1.  High human papillomavirus oncogene mRNA expression and not viral DNA load is associated with poor prognosis in cervical cancer patients.

Authors:  Marjon A de Boer; Ekaterina S Jordanova; Gemma G Kenter; Alexander A Peters; Willem E Corver; J Baptist Trimbos; Gert Jan Fleuren
Journal:  Clin Cancer Res       Date:  2007-01-01       Impact factor: 12.531

2.  Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas.

Authors:  J P Klussmann; S J Weissenborn; U Wieland; V Dries; J Kolligs; M Jungehuelsing; H E Eckel; H P Dienes; H J Pfister; P G Fuchs
Journal:  Cancer       Date:  2001-12-01       Impact factor: 6.860

Review 3.  Human papillomavirus-associated head and neck squamous cell carcinoma: mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers.

Authors:  M L Gillison; K V Shah
Journal:  Curr Opin Oncol       Date:  2001-05       Impact factor: 3.645

4.  Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.

Authors:  M L Gillison; W M Koch; R B Capone; M Spafford; W H Westra; L Wu; M L Zahurak; R W Daniel; M Viglione; D E Symer; K V Shah; D Sidransky
Journal:  J Natl Cancer Inst       Date:  2000-05-03       Impact factor: 13.506

Review 5.  Human papillomaviruses and associated malignancies.

Authors:  R M Alani; K Münger
Journal:  J Clin Oncol       Date:  1998-01       Impact factor: 44.544

6.  Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control.

Authors:  T Andl; T Kahn; A Pfuhl; T Nicola; R Erber; C Conradt; W Klein; M Helbig; A Dietz; H Weidauer; F X Bosch
Journal:  Cancer Res       Date:  1998-01-01       Impact factor: 12.701

7.  The incidence of tonsillar cancer in Sweden is increasing.

Authors:  Lalle Hammarstedt; Hanna Dahlstrand; David Lindquist; Liselotte Onelöv; Michael Ryott; Juhua Luo; Tina Dalianis; Weimin Ye; Eva Munck-Wikland
Journal:  Acta Otolaryngol       Date:  2007-09       Impact factor: 1.494

8.  Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil.

Authors:  Wei Li; Carol H Thompson; Christopher J O'Brien; Edward B McNeil; Richard A Scolyer; Yvonne E Cossart; Michael J Veness; D Murray Walker; Gary J Morgan; Barbara R Rose
Journal:  Int J Cancer       Date:  2003-09-10       Impact factor: 7.396

Review 9.  HPV infections and tonsillar carcinoma.

Authors:  S Syrjänen
Journal:  J Clin Pathol       Date:  2004-05       Impact factor: 3.411

10.  Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx.

Authors:  Justine M Ritchie; Elaine M Smith; Kurt F Summersgill; Henry T Hoffman; Donghong Wang; Jens P Klussmann; Lubomir P Turek; Thomas H Haugen
Journal:  Int J Cancer       Date:  2003-04-10       Impact factor: 7.396
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  72 in total

Review 1.  HPV-associated head and neck cancer: a virus-related cancer epidemic.

Authors:  Shanthi Marur; Gypsyamber D'Souza; William H Westra; Arlene A Forastiere
Journal:  Lancet Oncol       Date:  2010-05-05       Impact factor: 41.316

2.  Human papillomavirus and survival of patients with oropharyngeal cancer.

Authors:  K Kian Ang; Jonathan Harris; Richard Wheeler; Randal Weber; David I Rosenthal; Phuc Felix Nguyen-Tân; William H Westra; Christine H Chung; Richard C Jordan; Charles Lu; Harold Kim; Rita Axelrod; C Craig Silverman; Kevin P Redmond; Maura L Gillison
Journal:  N Engl J Med       Date:  2010-06-07       Impact factor: 91.245

3.  mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas.

Authors:  Alfredo A Molinolo; Christina Marsh; Mohamed El Dinali; Nitin Gangane; Kaitlin Jennison; Stephen Hewitt; Vyomesh Patel; Tanguy Y Seiwert; J Silvio Gutkind
Journal:  Clin Cancer Res       Date:  2012-03-12       Impact factor: 12.531

4.  p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status.

Authors:  James S Lewis; Wade L Thorstad; Rebecca D Chernock; Bruce H Haughey; James H Yip; Qin Zhang; Samir K El-Mofty
Journal:  Am J Surg Pathol       Date:  2010-08       Impact factor: 6.394

Review 5.  Human papillomavirus in head and neck tumors: epidemiological, molecular and clinical aspects.

Authors:  Jan Klozar; Ruth Tachezy; Eliška Rotnáglová; Eva Košlabová; Martina Saláková; Eva Hamšíková
Journal:  Wien Med Wochenschr       Date:  2010-06

6.  Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancer.

Authors:  Luc G T Morris; Andrew G Sikora; Snehal G Patel; Richard B Hayes; Ian Ganly
Journal:  J Clin Oncol       Date:  2010-12-28       Impact factor: 44.544

7.  Cisplatin-based chemoradiotherapy vs. cetuximab-based bioradiotherapy for p16-positive oropharyngeal cancer: an updated meta-analysis including trials RTOG 1016 and De-ESCALaTE.

Authors:  Petar Suton; Marko Skelin; Zoran Rakusic; Stjepan Dokuzovic; Ivica Luksic
Journal:  Eur Arch Otorhinolaryngol       Date:  2019-03-18       Impact factor: 2.503

8.  Inflammatory markers as prognostic factors of recurrence in advanced-stage squamous cell carcinoma of the head and neck.

Authors:  M Valdes; J Villeda; H Mithoowani; T Pitre; M Chasen
Journal:  Curr Oncol       Date:  2020-06-01       Impact factor: 3.677

9.  Trends in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma Incidence, Vermont 1999-2013.

Authors:  Adepitan A Owosho; Rashidah Wiley; Tessie Stansbury; Semiu O Gbadamosi; Jon S Ryder
Journal:  J Community Health       Date:  2018-08

10.  Role of human papillomavirus in the pathogenesis of oral squamous cell carcinoma.

Authors:  Anastasios K Markopoulos
Journal:  World J Exp Med       Date:  2012-08-20
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