Literature DB >> 19383246

Recombinant human erythropoietin protects against experimental spinal cord trauma injury by regulating expression of the proteins MKP-1 and p-ERK.

H Huang1, S Fan, X Ji, Y Zhang, F Bao, G Zhang.   

Abstract

The present study explored the tissue-protective effect of erythropoietin in rats after experimental spinal cord injury (SCI) produced by dropping a weight onto surgically exposed spinal cord. Sixty rats were randomized to sham operation (spinal cord exposure; control), SCI plus intraperitoneal saline injection, or SCI plus intraperitoneal erythropoietin injection. Locomotor function was evaluated with Basso, Beattie and Bresnahan scores 1 day (24 h) and 7 days later, and rats were then killed for analysis of lesion site tissue. Compared with saline-treated SCI rats, erythropoietin-treated SCI rats showed significantly less locomotor dysfunction and faster locomotor recovery. Immunohistochemistry showed that erythropoietin-treated SCI rats had a significantly lower phospho-extracellular signal-regulated kinase (p-ERK) protein expression and a significantly higher mitogen-activated protein kinase phosphatase-1 (MKP-1) protein expression than saline-treated SCI rats. Haematoxylin-eosin staining showed progressive disruption of dorsal white matter and neuron loss after SCI; lesions were less severe and there was more neuron regeneration in the erythropoietin group than in the saline group. It is concluded that erythropoietin reduces pathological changes and SCI severity via down-regulation of p-ERK and up-regulation of MKP-1.

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Year:  2009        PMID： 19383246     DOI： 10.1177/147323000903700227

Source DB:  PubMed          Journal:  J Int Med Res        ISSN： 0300-0605            Impact factor:   1.671


  14 in total

Review 1.  A grading system to evaluate objectively the strength of pre-clinical data of acute neuroprotective therapies for clinical translation in spinal cord injury.

Authors:  Brian K Kwon; Elena B Okon; Eve Tsai; Michael S Beattie; Jacqueline C Bresnahan; David K Magnuson; Paul J Reier; Dana M McTigue; Phillip G Popovich; Andrew R Blight; Martin Oudega; James D Guest; Lynne C Weaver; Michael G Fehlings; Wolfram Tetzlaff
Journal:  J Neurotrauma       Date:  2010-10-18       Impact factor: 5.269

Review 2.  Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease.

Authors:  Louise M Collins; Eric J Downer; André Toulouse; Yvonne M Nolan
Journal:  Mol Neurobiol       Date:  2014-06-24       Impact factor: 5.590

Review 3.  A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury.

Authors:  Brian K Kwon; Elena Okon; Jessica Hillyer; Cody Mann; Darryl Baptiste; Lynne C Weaver; Michael G Fehlings; Wolfram Tetzlaff
Journal:  J Neurotrauma       Date:  2010-04-14       Impact factor: 5.269

4.  A nonerythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock.

Authors:  Nimesh S A Patel; Kiran K Nandra; Michael Brines; Massimo Collino; Ws Fred Wong; Amar Kapoor; Elisa Benetti; Fera Y Goh; Roberto Fantozzi; Anthony Cerami; Christoph Thiemermann
Journal:  Mol Med       Date:  2011-05-13       Impact factor: 6.354

5.  Beneficial effect of interleukin-1 receptor antagonist protein on spinal cord injury recovery in the rat.

Authors:  Shaohui Zong; Gaofeng Zeng; Bo Wei; Chunxiang Xiong; Yuxi Zhao
Journal:  Inflammation       Date:  2012-04       Impact factor: 4.092

6.  The role of the JAK-STAT pathway in neural stem cells, neural progenitor cells and reactive astrocytes after spinal cord injury.

Authors:  Tianyi Wang; Wenqi Yuan; Yong Liu; Yanjun Zhang; Zhijie Wang; Xianhu Zhou; Guangzhi Ning; Liang Zhang; Liwei Yao; Shiqing Feng; Xiaohong Kong
Journal:  Biomed Rep       Date:  2014-12-11

7.  Novel approach to an early assessment of a patient's potential for neurological remission after acute spinal cord injury: Analysis of hemoglobin concentration dynamics.

Authors:  Bahram Biglari; Raban Arved Heller; Manuel Hörner; Andre Sperl; Tobias Bock; Bruno Reible; Patrick Haubruck; Paul Alfred Grützner; Arash Moghaddam
Journal:  J Spinal Cord Med       Date:  2019-06-18       Impact factor: 1.985

8.  Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain.

Authors:  Russell P Landry; Elena Martinez; Joyce A DeLeo; E Alfonso Romero-Sandoval
Journal:  J Pain       Date:  2012-08-14       Impact factor: 5.820

9.  Proteomic Analysis of the Spatio-temporal Based Molecular Kinetics of Acute Spinal Cord Injury Identifies a Time- and Segment-specific Window for Effective Tissue Repair.

Authors:  Stephanie Devaux; Dasa Cizkova; Jusal Quanico; Julien Franck; Serge Nataf; Laurent Pays; Lena Hauberg-Lotte; Peter Maass; Jan H Kobarg; Firas Kobeissy; Céline Mériaux; Maxence Wisztorski; Lucia Slovinska; Juraj Blasko; Viera Cigankova; Isabelle Fournier; Michel Salzet
Journal:  Mol Cell Proteomics       Date:  2016-06-01       Impact factor: 5.911

10.  The impact of erythropoietin on short-term changes in phosphorylation of brain protein kinases in a rat model of traumatic brain injury.

Authors:  Samuel Valable; Gilles Francony; Pierre Bouzat; Marie-Cécile Fevre; Nouara Mahious; Valentine Bouet; Régine Farion; Emmanuel Barbier; Hana Lahrech; Chantal Remy; Edwige Petit; Christoph Segebarth; Myriam Bernaudin; Jean-François Payen
Journal:  J Cereb Blood Flow Metab       Date:  2009-10-07       Impact factor: 6.200
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