Literature DB >> 1938252

Chemiluminescence of neutrophils in patients with glomerulonephritis treated with methylprednisolone.

J Kuźniar1, W Sajewicz, W Kopeć, Z Hruby.   

Abstract

The effect of high dose methylprednisolone (Solu-Medrol, Up John) (1000 mg) on chemiluminescence (CL) of peripheral blood neutrophils in patients with various primary glomerulopathies was determined. Contrary to the well-established influence of corticosteroids on in vitro suppression of leukocytic chemiluminescence, our studies disclose a remarkable enhancement of neutrophil chemiluminescent activity in patients receiving pulse methylprednisolone infusion. Subsequent administrations of the drug did not result in any significant change of the analysed parameters. Increased chemiluminescence returned to the pretreatment values within approximately seven days. A possible explanation for the observed phenomenon is discussed.

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Year:  1991        PMID： 1938252     DOI： 10.1007/bf02583999

Source DB:  PubMed          Journal:  Int Urol Nephrol        ISSN： 0301-1623            Impact factor:   2.370


  29 in total

1.  THE EFFECT OF ADRENAL GLUCOCORTICOSTEROIDS UPON THE CELLULAR COMPOSITION OF INFLAMMATORY EXUDATES.

Authors:  D R BOGGS; J W ATHENS; G E CARTWRIGHT; M M WINTROBE
Journal:  Am J Pathol       Date:  1964-05       Impact factor: 4.307

2.  Influence of corticosteroids on human polymorphonuclear leukocyte function in vitro : Reduction of lysosomal enzyme release and superoxide production.

Authors:  I M Goldstein; D Roos; G Weissmann; H B Kaplan
Journal:  Inflammation       Date:  1976-06       Impact factor: 4.092

3.  Effect of anti-inflammatory drugs and agents that elevate intracellular cyclic AMP on the release of toxic oxygen metabolites by phagocytes: studies in a model of tissue-bound IgG.

Authors:  J E Lehmeyer; R B Johnston
Journal:  Clin Immunol Immunopathol       Date:  1978-04

4.  Leukocyte chemotaxis in vivo. II. Analysis of the selective inhibition of neutrophil or mononuclear cell accumulation.

Authors:  R J Perper; M Sanda; G Chinea; A L Oronsky
Journal:  J Lab Clin Med       Date:  1974-09

5.  Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.

Authors:  S J Weiss; S Regiani
Journal:  J Clin Invest       Date:  1984-05       Impact factor: 14.808

6.  New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.

Authors:  R J Johnson; W G Couser; E Y Chi; S Adler; S J Klebanoff
Journal:  J Clin Invest       Date:  1987-05       Impact factor: 14.808

7.  Comparison of agents producing a neutrophilic leukocytosis in man. Hydrocortisone, prednisone, endotoxin, and etiocholanolone.

Authors:  D C Dale; A S Fauci; I V Guerry D; S M Wolff
Journal:  J Clin Invest       Date:  1975-10       Impact factor: 14.808

8.  The mechanism of action of a single dose of methylprednisolone on acute inflammation in vivo.

Authors:  S L Wiener; R Wiener; M Urivetzky; S Shafer; H D Isenberg; C Janov; E Meilman
Journal:  J Clin Invest       Date:  1975-09       Impact factor: 14.808

9.  Corticosteroids inhibit complement-induced granulocyte aggregation. A possible mechanism for their efficacy in shock states.

Authors:  D E Hammerschmidt; J G White; P R Craddock; H S Jacob
Journal:  J Clin Invest       Date:  1979-04       Impact factor: 14.808

10.  A ROLE OF POLYMORPHONUCLEAR LEUKOCYTES AND COMPLEMENT IN NEPHROTOXIC NEPHRITIS.

Authors:  C G COCHRANE; E R UNANUE; F J DIXON
Journal:  J Exp Med       Date:  1965-07-01       Impact factor: 14.307
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  1 in total

1.  The effect of prednisolone on canine neutrophil function: in vivo and in vitro studies.

Authors:  G Trowald-Wigh; L Håkansson; A Johannisson; L E Edqvist
Journal:  Acta Vet Scand       Date:  1998       Impact factor: 1.695
  1 in total

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