Literature DB >> 19381933

Histone chaperone as coactivator of chromatin transcription: role of acetylation.

Shrikanth S Gadad1, Jayasha Shandilya, Venkatesh Swaminathan, Tapas K Kundu.   

Abstract

Histone chaperones are a group of histone-interacting proteins, involved in several important cellular functions. These chaperones are essential to facilitate ordered assembly of nucleosomes, both in replication dependent and independent manner. Replication independent function of histone chaperone is necessary for histone eviction during transcriptional initiation and elongation. In this chapter we have discussed a method to evaluate the role of histone chaperone NPM1 (the only known chaperone to get acetylated with functional consequence) in the transcriptional activation which is acetylation dependent.

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Year:  2009        PMID： 19381933     DOI： 10.1007/978-1-59745-190-1_18

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  2 in total

1.  Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.

Authors:  Arati Khanna-Gupta; Nirmalee Abayasekara; Michelle Levine; Hong Sun; Maria Virgilio; Navid Nia; Stephanie Halene; Paolo Sportoletti; Jee-Yeong Jeong; Pier Paolo Pandolfi; Nancy Berliner
Journal:  J Biol Chem       Date:  2012-07-31       Impact factor: 5.157

2.  The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation.

Authors:  Yaser Heshmati; Shabnam Kharazi; Gözde Türköz; David Chang; Esmat Kamali Dolatabadi; Johan Boström; Aleksandra Krstic; Theodora Boukoura; Emma Wagner; Nadir Kadri; Robert Månsson; Mikael Altun; Hong Qian; Julian Walfridsson
Journal:  Sci Rep       Date:  2018-07-25       Impact factor: 4.379
  2 in total

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