Literature DB >> 19381670

A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines.

Takenori Ogawa1, Toru Furukawa, Kiyoto Shiga, Sho Hashimoto, Kazumi Ogawa, Toshimitsu Kobayashi, Akira Horii.   

Abstract

We analyzed the cis-diamminedichloroplatinum (CDDP) susceptibility of ten head and neck squamous cell carcinoma (HNSCC) cell lines and found that this susceptibility varied significantly among the cell lines. Apoptotic cell death was predominant after the CDDP treatment, and a significant association was observed between the induction of apoptosis and the CDDP susceptibility. An analysis using a cDNA microarray consisting of 23,040 genes identified 52 genes that showed altered expression patterns between super-sensitive and super-resistant cell lines after the CDDP treatments. Using these 52 genes, we successfully distinguished the super-resistant cell lines from others. Our present results give us valuable clues to better understand the chemosensitivities of such cells to CDDP. This will improve the clinical management of patients with HNSCC.

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Year:  2010        PMID： 19381670     DOI： 10.1007/s00405-009-0976-x

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  27 in total

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2.  Recent advances in head and neck cancer.

Authors:  Robert I Haddad; Dong M Shin
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3.  Parallel human genome analysis: microarray-based expression monitoring of 1000 genes.

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5.  An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines.

Authors:  L K Hosking; R D Whelan; S A Shellard; P Bedford; B T Hill
Journal:  Biochem Pharmacol       Date:  1990-10-15       Impact factor: 5.858

6.  Supradose intra-arterial cisplatin and concurrent radiation therapy for the treatment of stage IV head and neck squamous cell carcinoma is feasible and efficacious in a multi-institutional setting: results of Radiation Therapy Oncology Group Trial 9615.

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7.  Chemosensitivity of solid tumor cells in vitro is related to activation of the CD95 system.

Authors:  S Fulda; M Los; C Friesen; K M Debatin
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8.  Formation of nuclear Bax/p53 complexes is associated with chemotherapy induced apoptosis.

Authors:  A J Raffo; A L Kim; R L Fine
Journal:  Oncogene       Date:  2000-12-14       Impact factor: 9.867

9.  Relationship of cellular glutathione to the cytotoxicity and resistance of seven platinum compounds.

Authors:  C Meijer; N H Mulder; H Timmer-Bosscha; W J Sluiter; G J Meersma; E G de Vries
Journal:  Cancer Res       Date:  1992-12-15       Impact factor: 12.701

10.  Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis.

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Journal:  Lab Invest       Date:  2004-10       Impact factor: 5.662
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  1 in total

1.  Upregulation of IGF2 is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma.

Authors:  Takenori Ogawa; Kazumi Ogawa; Kiyoto Shiga; Toru Furukawa; Hiroki Nagase; Sho Hashimoto; Toshimitsu Kobayashi; Akira Horii
Journal:  Eur Arch Otorhinolaryngol       Date:  2010-05-05       Impact factor: 2.503
  1 in total

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