OBJECTIVE: To investigate the role of spinocerebellar ataxia type 17 (SCA17) in the development of parkinsonism. METHOD: We screened 1,155 parkinsonian patients (931 with Parkinson disease and 224 with multiple system atrophy) and 400 normal subjects for SCA17. 99mTc-TRODAT-1 SPECT was used to evaluate the striatal dopamine transporter (DAT) status. RESULTS: Trinucleotide expansion in the SCA17 gene was found in 10 parkinsonian patients (8 with Parkinson disease, 2 with multiple system atrophy) using 42 repeats as an upper normal limit. The repeat sizes in the patients ranged from 43 to 46, which are considered to be low-range expansions. All patients had interrupted sequences. Three probands and three asymptomatic carriers underwent 99mTc-TRODAT-1 SPECT. Striatal DAT binding was markedly reduced in all probands and mildly decreased in one asymptomatic carrier. Among the 400 normal control subjects, there was one individual with an expansion of 44 repeats, another with 43 repeats, and two with 42 repeats. Striatal DAT binding was decreased not only in the control subjects with 44 or 43 repeats, but in ones with 42 repeats, suggesting that an expansion as low as 42 repeats might constitute a susceptibility gene for parkinsonism. CONCLUSIONS: Low-range expansion of the SCA17 gene is not a rare genetic cause of parkinsonism without ataxia in our population. Reduced penetrance or variable expressivity in low-range expansion might be an explanation for the blurred cutoff point for normal expansion in SCA17.
OBJECTIVE: To investigate the role of spinocerebellar ataxia type 17 (SCA17) in the development of parkinsonism. METHOD: We screened 1,155 parkinsonianpatients (931 with Parkinson disease and 224 with multiple system atrophy) and 400 normal subjects for SCA17. 99mTc-TRODAT-1 SPECT was used to evaluate the striatal dopamine transporter (DAT) status. RESULTS:Trinucleotide expansion in the SCA17 gene was found in 10 parkinsonianpatients (8 with Parkinson disease, 2 with multiple system atrophy) using 42 repeats as an upper normal limit. The repeat sizes in the patients ranged from 43 to 46, which are considered to be low-range expansions. All patients had interrupted sequences. Three probands and three asymptomatic carriers underwent 99mTc-TRODAT-1 SPECT. Striatal DAT binding was markedly reduced in all probands and mildly decreased in one asymptomatic carrier. Among the 400 normal control subjects, there was one individual with an expansion of 44 repeats, another with 43 repeats, and two with 42 repeats. Striatal DAT binding was decreased not only in the control subjects with 44 or 43 repeats, but in ones with 42 repeats, suggesting that an expansion as low as 42 repeats might constitute a susceptibility gene for parkinsonism. CONCLUSIONS: Low-range expansion of the SCA17 gene is not a rare genetic cause of parkinsonism without ataxia in our population. Reduced penetrance or variable expressivity in low-range expansion might be an explanation for the blurred cutoff point for normal expansion in SCA17.
Authors: Kyeong Joo Kim; Jong-Min Kim; Yun Jun Bae; In-Young Yoon; Yoo Sun Song; Sang Eu Kim Journal: J Clin Sleep Med Date: 2019-01-15 Impact factor: 4.062
Authors: Lisa Wang; Jan O Aasly; Grazia Annesi; Soraya Bardien; Maria Bozi; Alexis Brice; Jonathan Carr; Sun J Chung; Carl Clarke; David Crosiers; Angela Deutschländer; Gertrud Eckstein; Matthew J Farrer; Stefano Goldwurm; Gaetan Garraux; Georgios M Hadjigeorgiou; Andrew A Hicks; Nobutaka Hattori; Christine Klein; Beom Jeon; Yun J Kim; Suzanne Lesage; Juei-Jueng Lin; Timothy Lynch; Peter Lichtner; Anthony E Lang; Vincent Mok; Barbara Jasinska-Myga; George D Mellick; Karen E Morrison; Grzegorz Opala; Lasse Pihlstrøm; Peter P Pramstaller; Sung S Park; Aldo Quattrone; Ekaterina Rogaeva; Owen A Ross; Leonidas Stefanis; Joanne D Stockton; Peter A Silburn; Jessie Theuns; Eng K Tan; Hiroyuki Tomiyama; Mathias Toft; Christine Van Broeckhoven; Ryan J Uitti; Karin Wirdefeldt; Zbigniew Wszolek; Georgia Xiromerisiou; Kuo-Chu Yueh; Yi Zhao; Thomas Gasser; Demetrius M Maraganore; Rejko Krüger; Manu Sharma Journal: Neurology Date: 2015-09-09 Impact factor: 9.910