| Literature DB >> 19380027 |
Antoine Harb1, Wei Tan, Gregory E Wilding, Minoo Battiwalla, Sheila N J Sait, Eunice S Wang, Meir Wetzler.
Abstract
The predisposition of monosomy 7 to diabetes insipidus (DI) in acute myeloid leukemia (AML) led us to ask whether AML associated with monosomy 7 and DI will differ from AML associated with other karyotype aberrations and DI and whether the outcome of patients with AML and DI will differ from those without DI. We describe 2 patients from Roswell Park Cancer Institute and discuss 29 additional cases from the literature. AML with monosomy 7 and DI (n = 25) had a trend towards a lower complete remission (p = 0.0936) and worse survival (p = 0.0480) than AML with other karyotype changes and DI (n = 6). Further, AML with monosomy 7 and DI had worse complete remission rate and overall survival than AML with monosomy 7 but without DI. In conclusion, it appears that AML with monosomy 7 and DI is a disease entity with specifically poor outcome.Entities:
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Year: 2009 PMID： 19380027 DOI： 10.1016/j.cancergencyto.2009.01.006
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608