Literature DB >> 19379795

Generation of retinal cells from mouse and human induced pluripotent stem cells.

Yasuhiko Hirami1, Fumitaka Osakada, Kazutoshi Takahashi, Keisuke Okita, Shinya Yamanaka, Hanako Ikeda, Nagahisa Yoshimura, Masayo Takahashi.   

Abstract

We previously reported a technique for generating retinal pigment epithelia (RPE) and putative photoreceptors from embryonic stem (ES) cells. Here we tested whether our procedure can promote retinal differentiation of mouse and human induced pluripotent stem cells (iPSCs). Treating iPSCs with Wnt and Nodal antagonists in suspension culture induced expression of markers of retinal progenitor cells and generated RPE cells. Subsequently, treatment with retinoic acid and taurine generated cells positive for photoreceptor markers in all but one human cell lines. We propose that iPSCs can be induced to differentiate into retinal cells which have a possibility to be used as patient-specific donor cells for transplantation therapies.

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Year:  2009        PMID： 19379795     DOI： 10.1016/j.neulet.2009.04.035

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  168 in total

1.  Derivation, culture and retinal pigment epithelial differentiation of human embryonic stem cells using human fibroblast feeder cells.

Authors:  Yun-Shan Zhang; Zhen-Yu Lu; Yang Yu; Xiao-Rong Li; Wen-Bo Li; Yi-Na Wang; Ying Geng
Journal:  J Assist Reprod Genet       Date:  2012-06-03       Impact factor: 3.412

Review 2.  Stemming vision loss with stem cells.

Authors:  Valentina Marchetti; Tim U Krohne; David F Friedlander; Martin Friedlander
Journal:  J Clin Invest       Date:  2010-09-01       Impact factor: 14.808

Review 3.  Retinal pigment epithelium differentiation of stem cells: current status and challenges.

Authors:  Basak E Uygun; Nripen Sharma; Martin Yarmush
Journal:  Crit Rev Biomed Eng       Date:  2009

4.  Generation and clonal isolation of retinal stem cells from human embryonic stem cells.

Authors:  Laura Clarke; Brian G Ballios; Derek van der Kooy
Journal:  Eur J Neurosci       Date:  2012-05-16       Impact factor: 3.386

5.  Differentiation of induced pluripotent stem cells of swine into rod photoreceptors and their integration into the retina.

Authors:  Liang Zhou; Wei Wang; Yongqing Liu; Juan Fernandez de Castro; Toshihiko Ezashi; Bhanu Prakash V L Telugu; R Michael Roberts; Henry J Kaplan; Douglas C Dean
Journal:  Stem Cells       Date:  2011-06       Impact factor: 6.277

Review 6.  Translating induced pluripotent stem cells from bench to bedside: application to retinal diseases.

Authors:  Alona O Cramer; Robert E MacLaren
Journal:  Curr Gene Ther       Date:  2013-04       Impact factor: 4.391

Review 7.  Use of human pluripotent stem cells to study and treat retinopathies.

Authors:  Karim Ben M'Barek; Florian Regent; Christelle Monville
Journal:  World J Stem Cells       Date:  2015-04-26       Impact factor: 5.326

8.  A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells.

Authors:  Julien Maruotti; Karl Wahlin; David Gorrell; Imran Bhutto; Gerard Lutty; Donald J Zack
Journal:  Stem Cells Transl Med       Date:  2013-04-12       Impact factor: 6.940

9.  Scaffolds and stem cells: delivery of cell transplants for retinal degenerations.

Authors:  Karl E Kador; Jeffrey L Goldberg
Journal:  Expert Rev Ophthalmol       Date:  2012-10-01

10.  Developing rods transplanted into the degenerating retina of Crx-knockout mice exhibit neural activity similar to native photoreceptors.

Authors:  Kohei Homma; Satoshi Okamoto; Michiko Mandai; Norimoto Gotoh; Harsha K Rajasimha; Yi-Sheng Chang; Shan Chen; Wei Li; Tiziana Cogliati; Anand Swaroop; Masayo Takahashi
Journal:  Stem Cells       Date:  2013-06       Impact factor: 6.277
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