Literature DB >> 19379742

Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase.

José Canales1, Ascensión Fernández, Joaquim Rui Rodrigues, Rui Ferreira, João Meireles Ribeiro, Alicia Cabezas, María Jesús Costas, José Carlos Cameselle.   

Abstract

Cyclic ADP-ribose (cADPR) metabolism in mammals is catalyzed by NAD glycohydrolases (NADases) that, besides forming ADP-ribose, form and hydrolyze the N(1)-glycosidic linkage of cADPR. Thus far, no cADPR phosphohydrolase was known. We tested rat ADP-ribose/CDP-alcohol pyrophosphatase (ADPRibase-Mn) and found that cADPR is an ADPRibase-Mn ligand and substrate. ADPRibase-Mn activity on cADPR was 65-fold less efficient than on ADP-ribose, the best substrate. This is similar to the ADP-ribose/cADPR formation ratio by NADases. The product of cADPR phosphohydrolysis by ADPRibase-Mn was N(1)-(5-phosphoribosyl)-AMP, suggesting a novel route for cADPR turnover.

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Year:  2009        PMID： 19379742     DOI： 10.1016/j.febslet.2009.04.023

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase.

Authors:  Alicia Cabezas; João Meireles Ribeiro; Joaquim Rui Rodrigues; Iralis López-Villamizar; Ascensión Fernández; José Canales; Rosa María Pinto; María Jesús Costas; José Carlos Cameselle
Journal:  PLoS One       Date:  2015-02-18       Impact factor: 3.240

2.  'Click cyclic ADP-ribose': a neutral second messenger mimic.

Authors:  Joanna M Swarbrick; Richard Graeff; Clive Garnham; Mark P Thomas; Antony Galione; Barry V L Potter
Journal:  Chem Commun (Camb)       Date:  2014-01-23       Impact factor: 6.222

Review 3.  Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?

Authors:  Ralf Fliegert; Winnie M Riekehr; Andreas H Guse
Journal:  Front Immunol       Date:  2020-08-11       Impact factor: 7.561

4.  Concise syntheses of trifluoromethylated cyclic and acyclic analogues of cADPR.

Authors:  Xiangchen Huang; Min Dong; Jian Liu; Kehui Zhang; Zhenjun Yang; Liangren Zhang; Lihe Zhang
Journal:  Molecules       Date:  2010-11-30       Impact factor: 4.411

5.  Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.

Authors:  Joaquim Rui Rodrigues; Ascensión Fernández; José Canales; Alicia Cabezas; João Meireles Ribeiro; María Jesús Costas; José Carlos Cameselle
Journal:  PLoS One       Date:  2012-07-27       Impact factor: 3.240

6.  Global mass spectrometry based metabolomics profiling of erythrocytes infected with Plasmodium falciparum.

Authors:  Theodore R Sana; D Benjamin Gordon; Steven M Fischer; Shane E Tichy; Norton Kitagawa; Cindy Lai; William L Gosnell; Sandra P Chang
Journal:  PLoS One       Date:  2013-04-09       Impact factor: 3.240

7.  Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase.

Authors:  João Meireles Ribeiro; José Canales; Alicia Cabezas; Joaquim Rui Rodrigues; Rosa María Pinto; Iralis López-Villamizar; María Jesús Costas; José Carlos Cameselle
Journal:  Sci Rep       Date:  2018-01-18       Impact factor: 4.379
  7 in total

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