Literature DB >> 1937973

Astemizole-induced ventricular arrhythmias: an unexpected cause of convulsions.

A Clark1, H Love.   

Abstract

Antihistamines are commonly used drugs. The more recent additions to the formulary are less sedative, but have been implicated as a cause of ventricular arrhythmias. We report a case in which a deliberate overdose of astemizole was associated with Mobitz type two heart block and prolongation of the QT interval, causing the so-called torsade-de-pointes ventricular tachycardia.

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Year:  1991        PMID: 1937973     DOI: 10.1016/0167-5273(91)90166-m

Source DB:  PubMed          Journal:  Int J Cardiol        ISSN: 0167-5273            Impact factor:   4.164


  7 in total

1.  Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine.

Authors:  S Matsumoto; Y Yamazoe
Journal:  Br J Clin Pharmacol       Date:  2001-02       Impact factor: 4.335

Review 2.  Comparative tolerability of second generation antihistamines.

Authors:  F Horak; U P Stübner
Journal:  Drug Saf       Date:  1999-05       Impact factor: 5.606

3.  Itraconazole prevents terfenadine metabolism and increases risk of torsades de pointes ventricular tachycardia.

Authors:  S Pohjola-Sintonen; M Viitasalo; L Toivonen; P Neuvonen
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

4.  Public health problems and the rapid estimation of the size of the population at risk. Torsades de pointes and the use of terfenadine and astemizole in The Netherlands.

Authors:  R M Herings; B H Stricker; H G Leufkens; A Bakker; F Sturmans; J Urquhart
Journal:  Pharm World Sci       Date:  1993-10-15

5.  Antihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2.

Authors:  Qiaqia Li; Kilia Y Liu; Qipeng Liu; Guangyu Wang; Weihua Jiang; Qingshu Meng; Yang Yi; Yongyong Yang; Rui Wang; Sen Zhu; Chao Li; Longxiang Wu; Dongyu Zhao; Lin Yan; Lili Zhang; Jung-Sun Kim; Xiongbing Zu; Anthony J Kozielski; Wei Qian; Jenny C Chang; Akash Patnaik; Kaifu Chen; Qi Cao
Journal:  Mol Cancer Ther       Date:  2020-08-27       Impact factor: 6.261

Review 6.  H1-receptor antagonists. Comparative tolerability and safety.

Authors:  F E Simons
Journal:  Drug Saf       Date:  1994-05       Impact factor: 5.606

Review 7.  Safety of antihistamines in children.

Authors:  A P Ten Eick; J L Blumer; M D Reed
Journal:  Drug Saf       Date:  2001       Impact factor: 5.228

  7 in total

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