BACKGROUND: Hemodialysis (HD)-related lower extremity (LE) muscle cramps are a common cause of morbidity in end-stage renal disease patients on maintenance HD. Numerous pharmacologic and physical measures have been tried with variable success rates. METHODS: Sequential compression devices (SCD) improve venous return (VR) and are commonly used to prevent LE deep venous thrombosis in hospitals. We hypothesized that LE cramps are triggered by stagnant venous flow during HD and are preventable by improving VR. We prospectively studied four adult patients (mean age 61 +/- 14 years) on thrice-weekly HD who experienced two or more episodes of LE cramping weekly in the month before the study. SCD were applied before each HD on both legs and compressions were intermittently applied at 40 mmHg during treatment. RESULTS: All four patients reported complete resolution of cramping during the study period that lasted 1 month or 12 consecutive dialysis treatments. CONCLUSION: Application of SCD to LE may prevent the generation of LE HD-related cramping in a select group of patients. Larger, controlled studies are needed to establish the utility of this noninvasive alternative for the prevention of LE HD-related cramps.
BACKGROUND: Hemodialysis (HD)-related lower extremity (LE) muscle cramps are a common cause of morbidity in end-stage renal diseasepatients on maintenance HD. Numerous pharmacologic and physical measures have been tried with variable success rates. METHODS: Sequential compression devices (SCD) improve venous return (VR) and are commonly used to prevent LE deep venous thrombosis in hospitals. We hypothesized that LE cramps are triggered by stagnant venous flow during HD and are preventable by improving VR. We prospectively studied four adult patients (mean age 61 +/- 14 years) on thrice-weekly HD who experienced two or more episodes of LE cramping weekly in the month before the study. SCD were applied before each HD on both legs and compressions were intermittently applied at 40 mmHg during treatment. RESULTS: All four patients reported complete resolution of cramping during the study period that lasted 1 month or 12 consecutive dialysis treatments. CONCLUSION: Application of SCD to LE may prevent the generation of LE HD-related cramping in a select group of patients. Larger, controlled studies are needed to establish the utility of this noninvasive alternative for the prevention of LE HD-related cramps.
Authors: Akshay Varghese; Eduardo Lacson; Jessica M Sontrop; Rey R Acedillo; Ahmed A Al-Jaishi; Sierra Anderson; Amit Bagga; Katie L Bain; Laura L Bennett; Clara Bohm; Pierre A Brown; Christopher T Chan; Brenden Cote; Varun Dev; Bonnie Field; Claire Harris; Shasikara Kalatharan; Mercedeh Kiaii; Amber O Molnar; Matthew J Oliver; Malvinder S Parmar; Melissa Schorr; Nikhil Shah; Samuel A Silver; D Michael Smith; Manish M Sood; Irina St Louis; Karthik K Tennankore; Stephanie Thompson; Marcello Tonelli; Hans Vorster; Blair Waldvogel; James Zacharias; Amit X Garg Journal: Can J Kidney Health Dis Date: 2020-10-22