Literature DB >> 19379003

Clavatadines C-E, guanidine alkaloids from the Australian sponge Suberea clavata.

Malcolm S Buchanan1, Anthony R Carroll, Deborah Wessling, Michael Jobling, Vicky M Avery, Rohan A Davis, Yunjiang Feng, John N A Hooper, Ronald J Quinn.   

Abstract

Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds aerophobin 1 (4), purealdin L (5), and aplysinamisine II (6) were isolated from extracts of the sponge Suberea clavata by bioassay-guided fractionation using a serine protease factor XIa assay. Their structures were determined by 1D and 2D NMR spectroscopy. Compounds 1-6 exhibited weak inhibition of factor XIa.

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Year:  2009        PMID： 19379003     DOI： 10.1021/np8008013

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

1.  Synthesis of spiro-fused pyrazolidoylisoxazolines.

Authors:  Kathryn G Guggenheim; Jeffrey D Butler; Phillip P Painter; Beth A Lorsbach; Dean J Tantillo; Mark J Kurth
Journal:  J Org Chem       Date:  2011-06-22       Impact factor: 4.354

2.  Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel .

Authors:  George R Pettit; Yuping Tang; Qingwen Zhang; Gregory T Bourne; Christoph A Arm; John E Leet; John C Knight; Robin K Pettit; Jean-Charles Chapuis; Dennis L Doubek; Franklin J Ward; Christine Weber; John N A Hooper
Journal:  J Nat Prod       Date:  2013-02-14       Impact factor: 4.050

3.  Mollenyne A, a long-chain chlorodibromohydrin amide from the sponge Spirastrella mollis.

Authors:  Brandon I Morinaka; Tadeusz F Molinski
Journal:  Org Lett       Date:  2011-11-16       Impact factor: 6.005

4.  Total Synthesis and Biological Evaluation of Clavatadines C-E.

Authors:  Kylee Maxfield; Morgan Payne; Stephen Chamberland
Journal:  ACS Omega       Date:  2022-06-22

Review 5.  Recent advances in the discovery and development of factor XI/XIa inhibitors.

Authors:  Rami A Al-Horani; Daniel K Afosah
Journal:  Med Res Rev       Date:  2018-05-04       Impact factor: 12.944

6.  Antiparasitic bromotyrosine derivatives from the marine sponge Verongula rigida.

Authors:  Elkin Galeano; Olivier P Thomas; Sara Robledo; Diana Munoz; Alejandro Martinez
Journal:  Mar Drugs       Date:  2011-10-14       Impact factor: 6.085

Review 7.  Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Nobuhiro Fusetani
Journal:  Mar Drugs       Date:  2013-07-16       Impact factor: 5.118

8.  Application of Networking Approaches to Assess the Chemical Diversity, Biogeography, and Pharmaceutical Potential of Verongiida Natural Products.

Authors:  James Lever; Robert Brkljača; Colin Rix; Sylvia Urban
Journal:  Mar Drugs       Date:  2021-10-18       Impact factor: 5.118

9.  Bioactive Bromotyrosine Derivatives from the Pacific Marine Sponge Suberea clavata (Pulitzer-Finali, 1982).

Authors:  Céline Moriou; Damien Lacroix; Sylvain Petek; Amr El-Demerdash; Rozenn Trepos; Tinihauarii Mareva Leu; Cristina Florean; Marc Diederich; Claire Hellio; Cécile Debitus; Ali Al-Mourabit
Journal:  Mar Drugs       Date:  2021-03-06       Impact factor: 5.118

10.  Synthesis and Cytotoxicity Evaluation of Spirocyclic Bromotyrosine Clavatadine C Analogs.

Authors:  Piyush A Patel; Tanja Bruun; Polina Ilina; Heidi Mäkkylä; Antti Lempinen; Jari Yli-Kauhaluoma; Päivi Tammela; Paula S Kiuru
Journal:  Mar Drugs       Date:  2021-07-20       Impact factor: 5.118
  10 in total

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