| Literature DB >> 1937868 |
Q Hamid1, M Azzawi, S Ying, R Moqbel, A J Wardlaw, C J Corrigan, B Bradley, S R Durham, J V Collins, P K Jeffery.
Abstract
Using in situ hybridization, we have investigated the expression of interleukin-5 (IL-5) mRNA in bronchial biopsies from asthmatics (n = 10) and controls (n = 9). The number of IL-5-nRNA-positive cells were compared with the number of CD25+ and EG2+ cells and total eosinophil counts. Specific hybridization signals for IL-5 mRNA were demonstrated in 6 out of the 10 asthmatic subjects but in none of the controls. The 6 IL-5-mRNA-positive asthmatics tended to have more severe disease and showed a significant increase in the degree of infiltration of the bronchial mucosa by activated T lymphocytes and eosinophils.Entities:
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Year: 1991 PMID： 1937868 DOI： 10.1159/000235353
Source DB: PubMed Journal: Int Arch Allergy Appl Immunol ISSN： 0020-5915