OBJECTIVE: The purpose of this study was to evaluate the basis for the racial/ethnic disparity in kidney allograft survival. METHODS: We conducted a retrospective study of 2130 patients who underwent kidney transplantation between January 1995 and December 2003. Patient and graft survivals were compared using Kaplan-Meier analysis. RESULTS: Black recipients were more likely than white recipients to have hepatitis C infection (24.6% vs 7.1%), current tobacco use (21.2% vs 13.1%), previous alcohol use (22.6% vs 9.7%), and past illicit drug use (13.6% vs 3.9%). Current employment was less common among blacks. Additionally, black recipients were more likely to have a prior kidney transplant (16.7% vs 11.0%) and to have a cadaver kidney donor (74% vs 56.5%). The 5-year allograft survival rate was 72% for whites and 59% for blacks (p < .01). Previous kidney transplantation, cadaveric donor, donor age, recipient employment status, and recipient tobacco use were associated with allograft survival in a Cox proportional hazard model. CONCLUSIONS: Graft survival rate in black kidney transplant recipients is significantly lower than whites, and this disparity can be partially explained by the low rate of live donors and a higher previous transplantation rate in blacks.
OBJECTIVE: The purpose of this study was to evaluate the basis for the racial/ethnic disparity in kidney allograft survival. METHODS: We conducted a retrospective study of 2130 patients who underwent kidney transplantation between January 1995 and December 2003. Patient and graft survivals were compared using Kaplan-Meier analysis. RESULTS: Black recipients were more likely than white recipients to have hepatitis C infection (24.6% vs 7.1%), current tobacco use (21.2% vs 13.1%), previous alcohol use (22.6% vs 9.7%), and past illicit drug use (13.6% vs 3.9%). Current employment was less common among blacks. Additionally, black recipients were more likely to have a prior kidney transplant (16.7% vs 11.0%) and to have a cadaver kidney donor (74% vs 56.5%). The 5-year allograft survival rate was 72% for whites and 59% for blacks (p < .01). Previous kidney transplantation, cadaveric donor, donor age, recipient employment status, and recipient tobacco use were associated with allograft survival in a Cox proportional hazard model. CONCLUSIONS: Graft survival rate in black kidney transplant recipients is significantly lower than whites, and this disparity can be partially explained by the low rate of live donors and a higher previous transplantation rate in blacks.
Authors: Adil H Haider; Valerie K Scott; Karim A Rehman; Catherine Velopulos; Jessica M Bentley; Edward E Cornwell; Waddah Al-Refaie Journal: J Am Coll Surg Date: 2013-01-11 Impact factor: 6.113
Authors: Kira L Newman; Stacey A Fedewa; Melanie H Jacobson; Andrew B Adams; Rebecca Zhang; Stephen O Pastan; Rachel E Patzer Journal: Transplantation Date: 2016-12 Impact factor: 4.939
Authors: J Hassanzadeh; A A Hashiani; A Rajaeefard; H Salahi; E Khedmati; F Kakaei; S Nikeghbalian; A Malek-Hossein Journal: Indian J Nephrol Date: 2010-10
Authors: A Almasi-Hashiani; A R Rajaeefard; J Hassanzade; H Salahi; S Nikeghbalian; P Janghorban; S A Malek-Hosseini Journal: Iran Red Crescent Med J Date: 2011-06-01 Impact factor: 0.611
Authors: Jaimin R Trivedi; Siddharth V Pahwa; Katherine R Whitehouse; Bradley M Ceremuga; Mark S Slaughter Journal: PLoS One Date: 2022-01-26 Impact factor: 3.240
Authors: Jeffrey Rogers; Colleen L Jay; Alan C Farney; Giuseppe Orlando; Marie L Jacobs; David Harriman; Venkat Gurram; Berjesh Sharda; Komal Gurung; Amber Reeves-Daniel; William Doares; Scott Kaczmorski; Alejandra Mena-Gutierrez; Natalia Sakhovskaya; Michael D Gautreaux; Robert J Stratta Journal: Clin Transplant Date: 2022-01-31 Impact factor: 3.456