OBJECTIVE: To investigate the profile of circulating inflammatory markers after percutaneous coronary intervention (PCI) in patients with AMI or stable angina pectoris (AP). MATERIAL AND METHODS: Twenty patients with AMI and 10 with stable AP were treated with PCI of a central coronary artery. Blood samples were drawn immediately before PCI, in the AP group and after 3 and 12 h, days 1, 3, 5, 7 and 14 in both groups. RESULTS: Interleukin 6 increased in both groups to time-point 12 h and day 1 (peak), being significantly higher in the AMI group compared to the AP group at 3 and 12 h, and also at days 1 and 3. A similar profile was demonstrated for CRP with significantly higher levels in the AMI group at days 1, 3 and 5 compared to the AP group. A slightly different pattern was shown for Interleukin 10 (IL-10) with significantly higher levels in the AMI group at 3 and 12 h, days 1 and 14 compared to the AP group. CONCLUSION: AMI patients treated with PCI experienced a marked short-term increase in pro-inflammatory mediators as well as IL-10 compared to patients with stable angina pectoris treated with PCI.
OBJECTIVE: To investigate the profile of circulating inflammatory markers after percutaneous coronary intervention (PCI) in patients with AMI or stable angina pectoris (AP). MATERIAL AND METHODS: Twenty patients with AMI and 10 with stable AP were treated with PCI of a central coronary artery. Blood samples were drawn immediately before PCI, in the AP group and after 3 and 12 h, days 1, 3, 5, 7 and 14 in both groups. RESULTS:Interleukin 6 increased in both groups to time-point 12 h and day 1 (peak), being significantly higher in the AMI group compared to the AP group at 3 and 12 h, and also at days 1 and 3. A similar profile was demonstrated for CRP with significantly higher levels in the AMI group at days 1, 3 and 5 compared to the AP group. A slightly different pattern was shown for Interleukin 10 (IL-10) with significantly higher levels in the AMI group at 3 and 12 h, days 1 and 14 compared to the AP group. CONCLUSION: AMI patients treated with PCI experienced a marked short-term increase in pro-inflammatory mediators as well as IL-10 compared to patients with stable angina pectoris treated with PCI.
Authors: Jasveen J Kandhai-Ragunath; Carine J M Doggen; Liefke C van der Heijden; Marlies M Kok; Paolo Zocca; Bjorn de Wagenaar; Cees Doelman; Harald T Jørstad; Ron J G Peters; Clemens von Birgelen Journal: Heart Vessels Date: 2018-03-14 Impact factor: 2.037