Literature DB >> 1937835

Properties of the B oligomer of pertussis toxin.

L Nencioni1, M G Pizza, G Volpini, M T De Magistris, F Giovannoni, R Rappuoli.   

Abstract

The B oligomer of pertussis toxin was purified from culture supernatants of Bordetella pertussis strains which do not secrete the S1 subunit. The purified B oligomer is devoid of toxicity for CHO cells and other in vivo properties of the toxin, such as leukocytosis and histamine sensitization, but it retains the abilities to agglutinate erythrocytes and to induce the proliferation of T lymphocytes. The B oligomer is also able to induce protective immunity in mice but is less potent than molecules containing the S1 subunit also.

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Year:  1991        PMID： 1937835      PMCID： PMC259109          DOI： 10.1128/iai.59.12.4732-4734.1991

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

1.  Mutants of pertussis toxin suitable for vaccine development.

Authors:  M Pizza; A Covacci; A Bartoloni; M Perugini; L Nencioni; M T De Magistris; L Villa; D Nucci; R Manetti; M Bugnoli
Journal:  Science       Date:  1989-10-27       Impact factor: 47.728

2.  Pertussis toxin effects on T lymphocytes are mediated through CD3 and not by pertussis toxin catalyzed modification of a G protein.

Authors:  L S Gray; K S Huber; M C Gray; E L Hewlett; V H Engelhard
Journal:  J Immunol       Date:  1989-03-01       Impact factor: 5.422

3.  Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity.

Authors:  M Pizza; A Bartoloni; A Prugnola; S Silvestri; R Rappuoli
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

4.  Adenine nucleotides promote dissociation of pertussis toxin subunits.

Authors:  D L Burns; C R Manclark
Journal:  J Biol Chem       Date:  1986-03-25       Impact factor: 5.157

5.  Role of the A subunit of pertussis toxin in alteration of Chinese hamster ovary cell morphology.

Authors:  D L Burns; J G Kenimer; C R Manclark
Journal:  Infect Immun       Date:  1987-01       Impact factor: 3.441

6.  Immune response to the B oligomer of pertussis toxin.

Authors:  J L Arciniega; D L Burns; E Garcia-Ortigoza; C R Manclark
Journal:  Infect Immun       Date:  1987-05       Impact factor: 3.441

7.  The standardization of an assay for pertussis toxin and antitoxin in microplate culture of Chinese hamster ovary cells.

Authors:  P Gillenius; E Jäätmaa; P Askelöf; M Granström; M Tiru
Journal:  J Biol Stand       Date:  1985-01

8.  Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule.

Authors:  K Nogimori; M Tamura; M Yajima; K Ito; T Nakamura; N Kajikawa; Y Maruyama; M Ui
Journal:  Biochim Biophys Acta       Date:  1984-09-28

9.  Immune response to dimeric subunits of the pertussis toxin B oligomer.

Authors:  S Z Hausman; D L Burns; V C Sickler; C R Manclark
Journal:  Infect Immun       Date:  1989-06       Impact factor: 3.441

10.  Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections.

Authors:  H Sato; A Ito; J Chiba; Y Sato
Journal:  Infect Immun       Date:  1984-11       Impact factor: 3.441
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  15 in total

1.  Use of pertussis toxin encoded by ptx genes from Bordetella bronchiseptica to model the effects of antigenic drift of pertussis toxin on antibody neutralization.

Authors:  S Z Hausman; D L Burns
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

2.  Role of pertussis toxin A subunit in neutrophil migration and vascular permeability.

Authors:  G A Brito; M H Souza; A A Melo-Filho; E L Hewlett; A A Lima; C A Flores; R A Ribeiro
Journal:  Infect Immun       Date:  1997-03       Impact factor: 3.441

3.  Confocal microscopy study of pertussis toxin and toxoids on CHO-cells.

Authors:  Yajun Tan; Roland A Fleck; Catpagavalli Asokanathan; Chun-Ting Yuen; Dorothy Xing; Shumin Zhang; Junzhi Wang
Journal:  Hum Vaccin Immunother       Date:  2013-01-04       Impact factor: 3.452

4.  Adjuvant immunotherapy of C6 glioma in rats with pertussis toxin.

Authors:  Mario Orozco-Morales; Francisco-Javier Sánchez-García; Patricia Guevara-Salazar; Oscar Arrieta; Norma Y Hernández-Pedro; Aurora Sánchez-García; Rodolfo Perez-Madrigal; Edgar Rangel-López; Benjamín Pineda; Julio Sotelo
Journal:  J Cancer Res Clin Oncol       Date:  2011-09-27       Impact factor: 4.553

5.  Role of ADP-ribosyltransferase activity of pertussis toxin in toxin-adhesin redundancy with filamentous hemagglutinin during Bordetella pertussis infection.

Authors:  S Alonso; K Pethe; N Mielcarek; D Raze; C Locht
Journal:  Infect Immun       Date:  2001-10       Impact factor: 3.441

Review 6.  Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies.

Authors:  Seema Mattoo; James D Cherry
Journal:  Clin Microbiol Rev       Date:  2005-04       Impact factor: 26.132

7.  Pertussis toxin activates platelets through an interaction with platelet glycoprotein Ib.

Authors:  K A Sindt; E L Hewlett; G T Redpath; R Rappuoli; L S Gray; S R Vandenberg
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

8.  Pertussis toxin signals through the TCR to initiate cross-desensitization of the chemokine receptor CXCR4.

Authors:  Olivia D Schneider; Alison A Weiss; William E Miller
Journal:  J Immunol       Date:  2009-05-01       Impact factor: 5.422

9.  A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins.

Authors:  M Roberts; A Bacon; R Rappuoli; M Pizza; I Cropley; G Douce; G Dougan; M Marinaro; J McGhee; S Chatfield
Journal:  Infect Immun       Date:  1995-06       Impact factor: 3.441

10.  Pertussis toxin utilizes proximal components of the T-cell receptor complex to initiate signal transduction events in T cells.

Authors:  Olivia D Schneider; Alison A Weiss; William E Miller
Journal:  Infect Immun       Date:  2007-06-11       Impact factor: 3.441
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