Literature DB >> 1937829

Gamma interferon-activated human macrophages and Toxoplasma gondii, Chlamydia psittaci, and Leishmania donovani: antimicrobial role of limiting intracellular iron.

H W Murray1, A M Granger, R F Teitelbaum.   

Abstract

Iron-saturated transferrin did not reverse the intracellular killing or inhibition of Toxoplasma gondii, Chlamydia psittaci, or Leishmania donovani by gamma interferon-activated human macrophages. Deferoxamine, an iron chelator, also did not impair replication within unstimulated macrophages. Limiting the availability of intracellular iron is an unlikely mechanism in human macrophage activity against these three diverse pathogens.

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Year:  1991        PMID： 1937829      PMCID： PMC259098          DOI： 10.1128/iai.59.12.4684-4686.1991

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

1.  Oxygen-independent inhibition of intracellular Chlamydia psittaci growth by human monocytes and interferon-gamma-activated macrophages.

Authors:  C D Rothermel; B Y Rubin; E A Jaffe; H W Murray
Journal:  J Immunol       Date:  1986-07-15       Impact factor: 5.422

2.  Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens.

Authors:  T F Byrd; M A Horwitz
Journal:  J Clin Invest       Date:  1991-07       Impact factor: 14.808

3.  Human mononuclear phagocyte antiprotozoal mechanisms: oxygen-dependent vs oxygen-independent activity against intracellular Toxoplasma gondii.

Authors:  H W Murray; B Y Rubin; S M Carriero; A M Harris; E A Jaffee
Journal:  J Immunol       Date:  1985-03       Impact factor: 5.422

4.  Activation of human monocyte-derived macrophages to kill schistosomula of Schistosoma mansoni in vitro.

Authors:  S L James; K W Cook; J K Lazdins
Journal:  J Immunol       Date:  1990-10-15       Impact factor: 5.422

5.  Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

Authors:  S L James; J Glaven
Journal:  J Immunol       Date:  1989-12-15       Impact factor: 5.422

6.  Gamma-interferon modulates human monocyte/macrophage transferrin receptor expression.

Authors:  R Taetle; J M Honeysett
Journal:  Blood       Date:  1988-06       Impact factor: 22.113

7.  Expression of the transferrin receptor on murine peritoneal macrophages is modulated by in vitro treatment with interferon gamma.

Authors:  T A Hamilton; P W Gray; D O Adams
Journal:  Cell Immunol       Date:  1984-12       Impact factor: 4.868

8.  Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

Authors:  T F Byrd; M A Horwitz
Journal:  J Clin Invest       Date:  1989-05       Impact factor: 14.808

9.  Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages.

Authors:  H W Murray; A Szuro-Sudol; D Wellner; M J Oca; A M Granger; D M Libby; C D Rothermel; B Y Rubin
Journal:  Infect Immun       Date:  1989-03       Impact factor: 3.441

10.  Killing of intracellular Leishmania donovani by human mononuclear phagocytes. Evidence for oxygen-dependent and -independent leishmanicidal activity.

Authors:  H W Murray; D M Cartelli
Journal:  J Clin Invest       Date:  1983-07       Impact factor: 14.808
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  12 in total

1.  Chlamydia trachomatis persistence in the female mouse genital tract: inducible nitric oxide synthase and infection outcome.

Authors:  K H Ramsey; G S Miranpuri; I M Sigar; S Ouellette; G I Byrne
Journal:  Infect Immun       Date:  2001-08       Impact factor: 3.441

2.  Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication.

Authors:  Wendy Niedelman; Joris K Sprokholt; Barbara Clough; Eva-Maria Frickel; Jeroen P J Saeij
Journal:  Infect Immun       Date:  2013-09-16       Impact factor: 3.441

3.  Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors.

Authors:  Leigh A Jones; Jean-Paul Anthony; Fiona L Henriquez; Russell E Lyons; Mohammad B Nickdel; Katharine C Carter; James Alexander; Craig W Roberts
Journal:  Immunology       Date:  2008-03-28       Impact factor: 7.397

4.  Maturation of the Legionella pneumophila-containing phagosome into a phagolysosome within gamma interferon-activated macrophages.

Authors:  Marina Santic; Maëlle Molmeret; Yousef Abu Kwaik
Journal:  Infect Immun       Date:  2005-05       Impact factor: 3.441

5.  Response of Chlamydia trachomatis serovar E to iron restriction in vitro and evidence for iron-regulated chlamydial proteins.

Authors:  J E Raulston
Journal:  Infect Immun       Date:  1997-11       Impact factor: 3.441

6.  Inhibition of Legionella pneumophila growth by gamma interferon in permissive A/J mouse macrophages: role of reactive oxygen species, nitric oxide, tryptophan, and iron(III).

Authors:  S J Gebran; Y Yamamoto; C Newton; T W Klein; H Friedman
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

Review 7.  Role of nitric oxide in parasitic infections.

Authors:  S L James
Journal:  Microbiol Rev       Date:  1995-12

8.  TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms.

Authors:  Sarah A Benson; Joel D Ernst
Journal:  PLoS One       Date:  2009-07-24       Impact factor: 3.240

9.  Chlamydia trachomatis alters iron-regulatory protein-1 binding capacity and modulates cellular iron homeostasis in HeLa-229 cells.

Authors:  Harsh Vardhan; Apurb R Bhengraj; Rajneesh Jha; Aruna Singh Mittal
Journal:  J Biomed Biotechnol       Date:  2009-08-16

10.  Iron overload favors the elimination of Leishmania infantum from mouse tissues through interaction with reactive oxygen and nitrogen species.

Authors:  Sílvia Vale-Costa; Sandra Gomes-Pereira; Carlos Miguel Teixeira; Gustavo Rosa; Pedro Nuno Rodrigues; Ana Tomás; Rui Appelberg; Maria Salomé Gomes
Journal:  PLoS Negl Trop Dis       Date:  2013-02-14
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