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Literature DB >> 1937786

The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections.

J Martinez¹, O Campetella, A C Frasch, J J Cazzulo.

Abstract

Antibodies against the major cysteine proteinase (cruzipain) from Trypanosoma cruzi were detected in human sera obtained from patients with chronic Chagas' disease. Not only the intact 60-kDa enzyme but also its 25-kDa self-proteolysis fragment are antigenic in vivo. Although T. cruzi antigens 13 and 36 also reacted with the apparently monospecific antiproteinase serum, the antigenicity of cruzipain to human patients is genuine, since its reactivity was not modified by the adsorption of human sera with the recombinant proteins 13 and 36.

Entities: Disease Species

Mesh：

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Year: 1991 PMID： 1937786 PMCID： PMC259030 DOI： 10.1128/iai.59.11.4275-4277.1991

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

13 in total

1. Diagnosis of Chagas disease using recombinant DNA technology.

Authors: A C Frasch; M B Reyes
Journal: Parasitol Today Date: 1990-04

2. Self-proteolysis of the cysteine proteinase, cruzipain, from Trypanosoma cruzi gives a major fragment corresponding to its carboxy-terminal domain.

Authors: U Hellman; C Wernstedt; J J Cazzulo
Journal: Mol Biochem Parasitol Date: 1991-01 Impact factor: 1.759

3. Subcellular localization of a cysteine proteinase from Trypanosoma cruzi.

Authors: E Bontempi; J Martinez; J J Cazzulo
Journal: Mol Biochem Parasitol Date: 1989-02 Impact factor: 1.759

4. Antigenic determinants of Trypanosoma cruzi defined by cloning of parasite DNA.

Authors: C F Ibañez; J L Affranchino; A C Frasch
Journal: Mol Biochem Parasitol Date: 1987-09 Impact factor: 1.759

5. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.

Authors: D B Smith; K S Johnson
Journal: Gene Date: 1988-07-15 Impact factor: 3.688

6. A major cysteine proteinase is developmentally regulated in Trypanosoma cruzi.

Authors: O Campetella; J Martínez; J J Cazzulo
Journal: FEMS Microbiol Lett Date: 1990-01-15 Impact factor: 2.742

7. Amino acid and carbohydrate composition of a lysosomal cysteine proteinase from Trypanosoma cruzi. Absence of phosphorylated mannose residues.

Authors: J J Cazzulo; U Hellman; R Couso; A J Parodi
Journal: Mol Biochem Parasitol Date: 1990-01-01 Impact factor: 1.759

8. Structural and functional identification of GP57/51 antigen of Trypanosoma cruzi as a cysteine proteinase.

Authors: A C Murta; P M Persechini; T de S Padron; W de Souza; J A Guimarães; J Scharfstein
Journal: Mol Biochem Parasitol Date: 1990-11 Impact factor: 1.759

9. Further characterization and partial amino acid sequence of a cysteine proteinase from Trypanosoma cruzi.

Authors: J J Cazzulo; R Couso; A Raimondi; C Wernstedt; U Hellman
Journal: Mol Biochem Parasitol Date: 1989-02 Impact factor: 1.759

10. Cysteine proteinase in Trypanosoma cruzi: immunocytochemical localization and involvement in parasite-host cell interaction.

Authors: T Souto-Padrón; O E Campetella; J J Cazzulo; W de Souza
Journal: J Cell Sci Date: 1990-07 Impact factor: 5.285

15 in total

1. Involvement of sulfates from cruzipain, a major antigen of Trypanosoma cruzi, in the interaction with immunomodulatory molecule Siglec-E.

Authors: Maximiliano R Ferrero; Anja M Heins; Luciana L Soprano; Diana M Acosta; Mónica I Esteva; Thomas Jacobs; Vilma G Duschak
Journal: Med Microbiol Immunol Date: 2015-06-06 Impact factor: 3.402

2. Substitution of cysteine 192 in a highly conserved Streptococcus pyogenes extracellular cysteine protease (interleukin 1beta convertase) alters proteolytic activity and ablates zymogen processing.

Authors: J M Musser; K Stockbauer; V Kapur; G W Rudgers
Journal: Infect Immun Date: 1996-06 Impact factor: 3.441

3. The NADP+-linked glutamate dehydrogenase from Trypanosoma cruzi: sequence, genomic organization and expression.

Authors: P Barderi; O Campetella; A C Frasch; J A Santomé; U Hellman; U Pettersson; J J Cazzulo
Journal: Biochem J Date: 1998-03-01 Impact factor: 3.857

4. Use of full-length recombinant calflagin and its c fragment for improvement of diagnosis of Trypanosoma cruzi infection.

Authors: Iván S Marcipar; Cintia Roodveldt; Gerardo Corradi; María L Cabeza; Maria Edileuza F Brito; Lucile M Floeter Winter; Alberto J Marcipar; Ariel M Silber
Journal: J Clin Microbiol Date: 2005-11 Impact factor: 5.948

5. Design, construction, and evaluation of a specific chimeric antigen to diagnose chagasic infection.

Authors: Sebastián Aguirre; Ariel M Silber; Maria Edileuza F Brito; María E Ribone; Claudia M Lagier; Iván S Marcipar
Journal: J Clin Microbiol Date: 2006-10 Impact factor: 5.948

Review 6. Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps.

Authors: V Balouz; F Agüero; C A Buscaglia
Journal: Adv Parasitol Date: 2016-11-14 Impact factor: 3.870

7. Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.

Authors: V Kapur; M W Majesky; L L Li; R A Black; J M Musser
Journal: Proc Natl Acad Sci U S A Date: 1993-08-15 Impact factor: 11.205

8. Cross-reactivity studies and differential serodiagnosis of human infections caused by Trypanosoma cruzi and Leishmania spp; use of immunoblotting and ELISA with a purified antigen (Ag163B6).

Authors: E L Malchiodi; M G Chiaramonte; N J Taranto; N W Zwirner; R A Margni
Journal: Clin Exp Immunol Date: 1994-09 Impact factor: 4.330

Review 9. Intermediate metabolism in Trypanosoma cruzi.

Authors: J J Cazzulo
Journal: J Bioenerg Biomembr Date: 1994-04 Impact factor: 2.945

10. Major cysteine protease (cruzipain) in Z3 sylvatic isolates of Trypanosoma cruzi from Rio de Janeiro, Brazil.

Authors: S A O Gomes; D Misael; B A Silva; D Feder; C S Silva; T C M Gonçalves; A L S Santos; J R Santos-Mallet
Journal: Parasitol Res Date: 2009-05-13 Impact factor: 2.289