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Literature DB >> 1937783

ADP-ribosylation of p21ras and related proteins by Pseudomonas aeruginosa exoenzyme S.

Abstract

Pseudomonas aeruginosa exoenzyme S ADP-ribosylates p21ras and several related proteins. ADP-ribosylation of p21ras does not alter interactions with guanine nucleotides. The ras-related GTP-binding proteins, including Rab3, Rab4, Ral, Rap1A, and Rap2, are also substrates; given these results, we propose a model for the role of exoenzyme S in pathogenesis.

Entities: Chemical Species

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Year: 1991 PMID： 1937783 PMCID： PMC259026 DOI： 10.1128/iai.59.11.4259-4262.1991

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

37 in total

Review 1. The GTPase superfamily: conserved structure and molecular mechanism.

Authors: H R Bourne; D A Sanders; F McCormick
Journal: Nature Date: 1991-01-10 Impact factor: 49.962

2. rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.

Authors: G Fischer von Mollard; G A Mignery; M Baumert; M S Perin; T J Hanson; P M Burger; R Jahn; T C Südhof
Journal: Proc Natl Acad Sci U S A Date: 1990-03 Impact factor: 11.205

3. Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins.

Authors: L A Feig; G M Cooper
Journal: Mol Cell Biol Date: 1988-06 Impact factor: 4.272

4. Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S.

Authors: J Coburn; R T Wyatt; B H Iglewski; D M Gill
Journal: J Biol Chem Date: 1989-05-25 Impact factor: 5.157

5. Exoenzyme S of Pseudomonas aeruginosa ADP-ribosylates the intermediate filament protein vimentin.

Authors: J Coburn; S T Dillon; B H Iglewski; D M Gill
Journal: Infect Immun Date: 1989-03 Impact factor: 3.441

6. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain.

Authors: H Adari; D R Lowy; B M Willumsen; C J Der; F McCormick
Journal: Science Date: 1988-04-22 Impact factor: 47.728

7. Assay and purification of cytosolic factor required for cholera toxin activity.

Authors: M Woolkalis; D M Gill; J Coburn
Journal: Methods Enzymol Date: 1988 Impact factor: 1.600

8. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

Authors: A Zahraoui; N Touchot; P Chardin; A Tavitian
Journal: J Biol Chem Date: 1989-07-25 Impact factor: 5.157

9. Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase.

Authors: A Sekine; M Fujiwara; S Narumiya
Journal: J Biol Chem Date: 1989-05-25 Impact factor: 5.157

10. The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

Authors: P Chardin; P Boquet; P Madaule; M R Popoff; E J Rubin; D M Gill
Journal: EMBO J Date: 1989-04 Impact factor: 11.598

40 in total

ADP-ribosylation of p21ras and related proteins by Pseudomonas aeruginosa exoenzyme S.

Review 1. The GTPase superfamily: conserved structure and molecular mechanism.

2. rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.

3. Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins.

4. Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S.

5. Exoenzyme S of Pseudomonas aeruginosa ADP-ribosylates the intermediate filament protein vimentin.

6. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain.

7. Assay and purification of cytosolic factor required for cholera toxin activity.

8. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.

9. Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase.

10. The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1. Differential sensitivity of human epithelial cells to Pseudomonas aeruginosa exoenzyme S.

2. Examination of the coordinate effects of Pseudomonas aeruginosa ExoS on Rac1.

3. Regulatory role of PopN and its interacting partners in type III secretion of Pseudomonas aeruginosa.

4. Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis.

5. Characterization of an ExoS Type III translocation-resistant cell line.

6. Functional analysis of exsC and exsB in regulation of exoenzyme S production by Pseudomonas aeruginosa.

7. A leucine-rich motif targets Pseudomonas aeruginosa ExoS within mammalian cells.

8. In vitro assays to monitor the activity of Pseudomonas aeruginosa Type III secreted proteins.

9. Expression of recombinant exoenzyme S of Pseudomonas aeruginosa.

Review 10. Bacterial pathogens commandeer Rab GTPases to establish intracellular niches.