INTRODUCTION: Recent studies have shown that subclinical inflammation is a part of type 2 diabetes mellitus. This study was designed to explore the relationships between low-grade inflammation and renal microangiopathy in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: Sixty patients with type 2 diabetes mellitus were included in the study and further divided into normoalbuminurics, microalbuminurics, and macroalbuminurics, of 20 patients each. We analyzed serum concentrations of high-sensitivity C-reactive protein (HS-CRP) and interleukin-6 (IL-6) and studied their correlation with proteinuria. The patients and a control group of 20 healthy individuals were followed-up for a period of 6 months and the markers measured again. RESULTS: A positive correlation was found between urinary albumin excretion and levels of HS-CRP (r = 0.781, P < .001) and IL-6 (r = 0.708, P < .001). The level of glcosylated hemoglobin (HbA1c) showed a significant positive correlation with urinary albumin excretion (r = 0.630, P < .001), CRP (r = 0.750, P < .001), and IL-6 (r = 0.680, P < .001). Levels of HbA1c, HS-CRP, and IL-6 significantly decreased in all three diabetic groups after 6 months of treatment. Also, the percentage of HbA1c decrement correlated well with the decrease percentage in HS-CRP (r = .277, P = .01). CONCLUSIONS: Inflammatory markers in early type 2 diabetic nephropathy are elevated and are independently associated with urinary albumin excretion. It is possible to hypothesize on the participation of locally released cytokines in the development of kidney damage.
INTRODUCTION: Recent studies have shown that subclinical inflammation is a part of type 2 diabetes mellitus. This study was designed to explore the relationships between low-grade inflammation and renal microangiopathy in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: Sixty patients with type 2 diabetes mellitus were included in the study and further divided into normoalbuminurics, microalbuminurics, and macroalbuminurics, of 20 patients each. We analyzed serum concentrations of high-sensitivity C-reactive protein (HS-CRP) and interleukin-6 (IL-6) and studied their correlation with proteinuria. The patients and a control group of 20 healthy individuals were followed-up for a period of 6 months and the markers measured again. RESULTS: A positive correlation was found between urinary albumin excretion and levels of HS-CRP (r = 0.781, P < .001) and IL-6 (r = 0.708, P < .001). The level of glcosylated hemoglobin (HbA1c) showed a significant positive correlation with urinary albumin excretion (r = 0.630, P < .001), CRP (r = 0.750, P < .001), and IL-6 (r = 0.680, P < .001). Levels of HbA1c, HS-CRP, and IL-6 significantly decreased in all three diabetic groups after 6 months of treatment. Also, the percentage of HbA1c decrement correlated well with the decrease percentage in HS-CRP (r = .277, P = .01). CONCLUSIONS: Inflammatory markers in early type 2 diabetic nephropathy are elevated and are independently associated with urinary albumin excretion. It is possible to hypothesize on the participation of locally released cytokines in the development of kidney damage.
Authors: Jennifer L Whitney; Christine Maric Bilkan; Kathryn Sandberg; Adam K Myers; Susan E Mulroney Journal: Biol Sex Differ Date: 2013-06-27 Impact factor: 5.027
Authors: I-Th Lampropoulou; M Stangou; A Papagianni; T Didangelos; F Iliadis; G Efstratiadis Journal: J Diabetes Res Date: 2014-12-22 Impact factor: 4.011
Authors: Xue Mei Fan; Chun Lian Huang; Yi Ming Wang; Ning Li; Qiong Lin Liang; Guo An Luo Journal: J Diabetes Res Date: 2018-02-22 Impact factor: 4.011