| Literature DB >> 19376705 |
Emanuela Micheli1, Caterina Maria Lombardo, Danilo D'Ambrosio, Marco Franceschin, Stephen Neidle, Maria Savino.
Abstract
The human telomeric G-quadruplex structure is a promising target for the design of cancer drugs. The selectivity of G-quadruplex ligands with respect to duplex genomic DNA is of especial importance. The high selectivity of polyamine conjugated perylene derivatives appears to be regulated by side-chain charge density, as indicated by data from a FRET melting assay and induced CD spectroscopy.Entities:
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Year: 2009 PMID： 19376705 DOI： 10.1016/j.bmcl.2009.03.106
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823