Literature DB >> 19376229

Antibody-mediated xenograft injury: mechanisms and protective strategies.

Richard N Pierson1.   

Abstract

The use of porcine organs for clinical transplantation is a promising potential solution to the shortage of human organs. Preformed anti-pig antibody is the primary cause of hyperacute rejection, while elicited antibody can contribute to subsequent "delayed" xenograft rejection. This article will review recent progress to overcome antibody mediated xenograft rejection, through modification of the host immunity and use of genetically engineered pig organs.

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Year:  2009        PMID： 19376229      PMCID： PMC2695451          DOI： 10.1016/j.trim.2009.03.008

Source DB:  PubMed          Journal:  Transpl Immunol        ISSN： 0966-3274            Impact factor:   1.708


  65 in total

1.  Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience.

Authors:  Kenji Kuwaki; Yau-Lin Tseng; Frank J M F Dor; Akira Shimizu; Stuart L Houser; Todd M Sanderson; Courtney J Lancos; Derek D Prabharasuth; Jane Cheng; Kathleen Moran; Yosuke Hisashi; Nicolas Mueller; Kazuhiko Yamada; Julia L Greenstein; Robert J Hawley; Clive Patience; Michel Awwad; Jay A Fishman; Simon C Robson; Henk-Jan Schuurman; David H Sachs; David K C Cooper
Journal:  Nat Med       Date:  2004-12-26       Impact factor: 53.440

2.  Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.

Authors:  Kazuhiko Yamada; Koji Yazawa; Akira Shimizu; Takehiro Iwanaga; Yosuke Hisashi; Matthew Nuhn; Patricia O'Malley; Shuji Nobori; Parsia A Vagefi; Clive Patience; Jay Fishman; David K C Cooper; Robert J Hawley; Julia Greenstein; Henk-Jan Schuurman; Michel Awwad; Megan Sykes; David H Sachs
Journal:  Nat Med       Date:  2004-12-26       Impact factor: 53.440

3.  Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts.

Authors:  F L Ierino; T Kozlowski; J B Siegel; A Shimizu; R B Colvin; P T Banerjee; D K Cooper; A B Cosimi; F H Bach; D H Sachs; S C Robson
Journal:  Transplantation       Date:  1998-12-15       Impact factor: 4.939

4.  Removal of primate xenoreactive natural antibodies by extracorporeal perfusion of pig kidneys and livers.

Authors:  A Azimzadeh; C Meyer; H Watier; J P Beller; M P Chenard-Neu; R Kieny; K Boudjema; D Jaeck; J Cinqualbre; P Wolf
Journal:  Transpl Immunol       Date:  1998-03       Impact factor: 1.708

5.  Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts.

Authors:  A E Fiane; T E Mollnes; V Videm; T Hovig; K Høgåsen; O J Mellbye; L Spruce; W T Moore; A Sahu; J D Lambris
Journal:  Xenotransplantation       Date:  1999-02       Impact factor: 3.907

6.  C1-inhibitor attenuates hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig-to-human perfusion model.

Authors:  A E Fiane; V Videm; H T Johansen; O J Mellbye; E W Nielsen; T E Mollnes
Journal:  Immunopharmacology       Date:  1999-05

7.  The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene.

Authors:  Julie Milland; Dale Christiansen; Brooke D Lazarus; Simon G Taylor; Pei Xiang Xing; Mauro S Sandrin
Journal:  J Immunol       Date:  2006-02-15       Impact factor: 5.422

8.  Evidence of human non-alpha-galactosyl antibodies involved in the hyperacute rejection of pig lungs and their removal by pig organ perfusion.

Authors:  P Macchiarini; R Oriol; A Azimzadeh; V de Montpreville; R Rieben; N Bovin; M Mazmanian; P Dartevelle
Journal:  J Thorac Cardiovasc Surg       Date:  1998-11       Impact factor: 5.209

9.  Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors.

Authors:  A Zaidi; M Schmoeckel; F Bhatti; P Waterworth; M Tolan; E Cozzi; G Chavez; G Langford; S Thiru; J Wallwork; D White; P Friend
Journal:  Transplantation       Date:  1998-06-27       Impact factor: 4.939

10.  Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.

Authors:  Daxin Chen; Michele Weber; John H McVey; Geoffrey Kemball-Cook; Edward G D Tuddenham; Robert I Lechler; Anthony Dorling
Journal:  Am J Transplant       Date:  2004-12       Impact factor: 8.086
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  14 in total

1.  Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection.

Authors:  Bao-Ngoc H Nguyen; Agnes M Azimzadeh; Carsten Schroeder; Thomas Buddensick; Tianshu Zhang; Amal Laaris; Megan Cochrane; Henk-Jan Schuurman; David H Sachs; James S Allan; Richard N Pierson
Journal:  Xenotransplantation       Date:  2011 Mar-Apr       Impact factor: 3.907

2.  Expression of human CD46 modulates inflammation associated with GalTKO lung xenograft injury.

Authors:  L Burdorf; T Stoddard; T Zhang; E Rybak; A Riner; C Avon; A Laaris; X Cheng; E Sievert; G Braileanu; A Newton; C J Phelps; D Ayares; A M Azimzadeh; R N Pierson
Journal:  Am J Transplant       Date:  2014-04-02       Impact factor: 8.086

3.  Does expression of a human complement-regulatory protein on xenograft cells protect them from systemic complement activation?

Authors:  Abhijit Jagdale; Huy Nguyen; Juan Li; KaLia Burnette; David Ayares; David K C Cooper; Hidetaka Hara
Journal:  Int J Surg       Date:  2020-09-25       Impact factor: 6.071

Review 4.  Lung xenotransplantation: recent progress and current status.

Authors:  Donald G Harris; Kevin J Quinn; Siamak Dahi; Lars Burdorf; Agnes M Azimzadeh; Richard N Pierson
Journal:  Xenotransplantation       Date:  2014-07-05       Impact factor: 3.907

Review 5.  Overcoming Coagulation Dysregulation in Pig Solid Organ Transplantation in Nonhuman Primates: Recent Progress.

Authors:  Liaoran Wang; David K C Cooper; Lars Burdorf; Yi Wang; Hayato Iwase
Journal:  Transplantation       Date:  2018-07       Impact factor: 4.939

Review 6.  Transplantable bioartificial pancreas devices: current status and future prospects.

Authors:  Barbara Ludwig; Stefan Ludwig
Journal:  Langenbecks Arch Surg       Date:  2015-06-16       Impact factor: 3.445

Review 7.  Lung xenotransplantation: a review.

Authors:  Chris Laird; Lars Burdorf; Richard N Pierson
Journal:  Curr Opin Organ Transplant       Date:  2016-06       Impact factor: 2.640

8.  Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model.

Authors:  Muhammad M Mohiuddin; Avneesh K Singh; Philip C Corcoran; Robert F Hoyt; Marvin L Thomas; Billeta G T Lewis; Michael Eckhaus; Nicole L Dabkowski; Aaron J Belli; Keith A Reimann; David Ayares; Keith A Horvath
Journal:  Xenotransplantation       Date:  2013-10-29       Impact factor: 3.907

Review 9.  Current status of xenotransplantation and prospects for clinical application.

Authors:  Richard N Pierson; Anthony Dorling; David Ayares; Michael A Rees; Jörg D Seebach; Jay A Fishman; Bernhard J Hering; David K C Cooper
Journal:  Xenotransplantation       Date:  2009 Sep-Oct       Impact factor: 3.907

10.  Transgenic pigs designed to express human α-galactosidase to avoid humoral xenograft rejection.

Authors:  J Zeyland; B Gawrońska; W Juzwa; J Jura; A Nowak; R Słomski; Z Smorąg; M Szalata; A Woźniak; D Lipiński
Journal:  J Appl Genet       Date:  2013-06-19       Impact factor: 3.240
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