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Literature DB >> 19376116

Effect of 1-methyladenine on thermodynamic stabilities of double-helical DNA structures.

Abstract

1-Methyladenine (m1A) alters T.A Watson-Crick to T.m1A Hoogsteen base pair. Owing to its conversion to N6-methyladenine (m6A) at higher temperatures, thermodynamic studies of m1A-containing DNAs using conventional melting methods are subject to the influence of m6A species. In this study, we applied nuclear magnetic resonance spectroscopy to determine the base pairing modes and effect of m1A on thermodynamic stability of double-helical DNA. The observed base pairing modes account for the destabilizing trend which follows the order T.m1A approximately G.m1A<A.m1A<C.m1A, providing insights into the m1A flipping process and enhancing our understandings of the mutagenicity of m1A.

Entities: Chemical Gene

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Year: 2009 PMID： 19376116 DOI： 10.1016/j.febslet.2009.04.017

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

12 in total

Review 1. Chemical and structural effects of base modifications in messenger RNA.

Authors: Emily M Harcourt; Anna M Kietrys; Eric T Kool
Journal: Nature Date: 2017-01-18 Impact factor: 49.962

2. Robust IR-based detection of stable and fractionally populated G-C⁺ and A-T Hoogsteen base pairs in duplex DNA.

Authors: Allison L Stelling; Yu Xu; Huiqing Zhou; Seung H Choi; Mary C Clay; Dawn K Merriman; Hashim M Al-Hashimi
Journal: FEBS Lett Date: 2017-06-19 Impact factor: 4.124

3. Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A.

Authors: Bharathwaj Sathyamoorthy; Honglue Shi; Huiqing Zhou; Yi Xue; Atul Rangadurai; Dawn K Merriman; Hashim M Al-Hashimi
Journal: Nucleic Acids Res Date: 2017-05-19 Impact factor: 16.971

4. Atomic structures of excited state A-T Hoogsteen base pairs in duplex DNA by combining NMR relaxation dispersion, mutagenesis, and chemical shift calculations.

Authors: Honglue Shi; Mary C Clay; Atul Rangadurai; Bharathwaj Sathyamoorthy; David A Case; Hashim M Al-Hashimi
Journal: J Biomol NMR Date: 2018-04-19 Impact factor: 2.835

5. Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically ¹³C- and ¹⁵N-Labeled DNA.

Authors: Huiqing Zhou; Bharathwaj Sathyamoorthy; Allison Stelling; Yu Xu; Yi Xue; Ying Zhang Pigli; David A Case; Phoebe A Rice; Hashim M Al-Hashimi
Journal: Biochemistry Date: 2019-04-05 Impact factor: 3.162

6. Infrared Spectroscopic Observation of a G-C⁺ Hoogsteen Base Pair in the DNA:TATA-Box Binding Protein Complex Under Solution Conditions.

Authors: Allison L Stelling; Amy Y Liu; Wenjie Zeng; Raul Salinas; Maria A Schumacher; Hashim M Al-Hashimi
Journal: Angew Chem Int Ed Engl Date: 2019-07-25 Impact factor: 15.336

7. m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs.

Authors: Huiqing Zhou; Isaac J Kimsey; Evgenia N Nikolova; Bharathwaj Sathyamoorthy; Gianmarc Grazioli; James McSally; Tianyu Bai; Christoph H Wunderlich; Christoph Kreutz; Ioan Andricioaei; Hashim M Al-Hashimi
Journal: Nat Struct Mol Biol Date: 2016-08-01 Impact factor: 15.369