| Literature DB >> 19375924 |
P Porcari1, S Capuani, E D'Amore, M Lecce, A La Bella, F Fasano, L M Migneco, R Campanella, B Maraviglia, F S Pastore.
Abstract
The aim of this study was to evaluate in vivo the boron biodistribution and pharmacokinetics of 4-borono-2-fluorophenylalanine ((19)F-BPA) using (19)F MR Imaging ((19)F MRI) and Spectroscopy ((19)F MRS). The correlation between the results obtained by both techniques, (19)F MRI on rat brain and (19)F MRS on blood samples, showed the maximum (19)F-BPA uptake in C6 glioma model at 2.5h after infusion determining the optimal irradiation time. Moreover, the effect of L-DOPA as potential enhancer of (19)F-BPA tumour intake was assessed using (19)F MRI.Entities:
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Year: 2009 PMID： 19375924 DOI： 10.1016/j.apradiso.2009.03.065
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513