OBJECTIVES: We sought to document the pregnancy and neurodevelopmental outcome in monochorionic diamniotic twin pregnancies and to identify risk factors for death and impairment. STUDY DESIGN: We conducted a prospective cohort study of 136 monochorionic twins followed up from the first trimester until infancy. RESULTS: A total of 122 (90%) pregnancies resulted in 2 survivors, 6 (4%) in 1 survivor and 8 (6%) in no survivor. In all, 230 (92%) of 250 surviving infants were assessed at a mean age of 24 months. Neurodevelopmental impairment was present in 22 (10%) infants. Death or impairment of 1 or both infants occurred in 28 (22%) of 126 pregnancies. Twin-to-twin transfusion syndrome and assisted conception increased the risk of both death and impairment, whereas early-onset discordant growth only increased the risk of death. CONCLUSION: The mortality in this prospective series was 8% and neurodevelopmental impairment occurred in 10% of infants.
OBJECTIVES: We sought to document the pregnancy and neurodevelopmental outcome in monochorionic diamniotic twin pregnancies and to identify risk factors for death and impairment. STUDY DESIGN: We conducted a prospective cohort study of 136 monochorionic twins followed up from the first trimester until infancy. RESULTS: A total of 122 (90%) pregnancies resulted in 2 survivors, 6 (4%) in 1 survivor and 8 (6%) in no survivor. In all, 230 (92%) of 250 surviving infants were assessed at a mean age of 24 months. Neurodevelopmental impairment was present in 22 (10%) infants. Death or impairment of 1 or both infants occurred in 28 (22%) of 126 pregnancies. Twin-to-twin transfusion syndrome and assisted conception increased the risk of both death and impairment, whereas early-onset discordant growth only increased the risk of death. CONCLUSION: The mortality in this prospective series was 8% and neurodevelopmental impairment occurred in 10% of infants.
Authors: Fiona Cheong-See; Ewoud Schuit; David Arroyo-Manzano; Asma Khalil; Jon Barrett; K S Joseph; Elizabeth Asztalos; Karien Hack; Liesbeth Lewi; Arianne Lim; Sophie Liem; Jane E Norman; John Morrison; C Andrew Combs; Thomas J Garite; Kimberly Maurel; Vicente Serra; Alfredo Perales; Line Rode; Katharina Worda; Anwar Nassar; Mona Aboulghar; Dwight Rouse; Elizabeth Thom; Fionnuala Breathnach; Soichiro Nakayama; Francesca Maria Russo; Julian N Robinson; Jodie M Dodd; Roger B Newman; Sohinee Bhattacharya; Selphee Tang; Ben Willem J Mol; Javier Zamora; Basky Thilaganathan; Shakila Thangaratinam Journal: BMJ Date: 2016-09-06
Authors: Karien E A Hack; Corine Koopman-Esseboom; Jan B Derks; Sjoerd G Elias; Martin J K de Kleine; Wim Baerts; Attie T J I Go; Arty H P Schaap; Mark A H B M van der Hoeven; Alex J Eggink; Krystyna M Sollie; Nynke Weisglas-Kuperus; Gerard H A Visser Journal: PLoS One Date: 2009-08-28 Impact factor: 3.240
Authors: Kaylee B Park; Teresa Chapman; Kimberly A Aldinger; Ghayda M Mirzaa; Jordan Zeiger; Anita Beck; Ian A Glass; Robert F Hevner; Anna C Jansen; Desiree A Marshall; Renske Oegema; Elena Parrini; Russell P Saneto; Cynthia J Curry; Judith G Hall; Renzo Guerrini; Richard J Leventer; William B Dobyns Journal: Am J Med Genet A Date: 2020-11-18 Impact factor: 2.802
Authors: Carmen J Marsit; Devin C Koestler; Debra Watson-Smith; Charlotte M Boney; James F Padbury; Francois Luks Journal: Clin Epigenetics Date: 2013-10-03 Impact factor: 6.551