Literature DB >> 19374131

Molecular modelling study of the 3D structure of the bovine viral diarrhea virus (BVDV) helicase.

Andrea Brancale1, Chrisanthy Vlachaki, Dimitrios Vlachakis.   

Abstract

Bovine viral diarrhea virus (BVDV) is a member of the Flaviviridae family of viruses and constitutes a very important pathogen for livestock around the world. The viral helicase is an enzyme essential for the proliferation and transmission of the virus. In this work a 3D-model of the BVDV helicase was produced using homology modelling techniques and the known 3D-structure of the hepatitis C helicase of the Flaviviridae family as template, in an attempt to provide the means for structure-based design of novel anti-BVDV agents.

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Year:  2008        PMID： 19374131

Source DB:  PubMed          Journal:  In Silico Biol        ISSN： 1386-6338


  5 in total

1.  Antibody Clustering Using a Machine Learning Pipeline that Fuses Genetic, Structural, and Physicochemical Properties.

Authors:  Louis Papageorgiou; Dimitris Maroulis; George P Chrousos; Elias Eliopoulos; Dimitrios Vlachakis
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

2.  Drugena: A Fully Automated Immunoinformatics Platform for the Design of Antibody-Drug Conjugates Against Neurodegenerative Diseases.

Authors:  Louis Papageorgiou; Eleni Papakonstantinou; Constantinos Salis; Eleytheria Polychronidou; Marianna Hagidimitriou; Dimitris Maroulis; Elias Eliopoulos; Dimitrios Vlachakis
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

3.  Structural Study of the DNA: Clock/Bmal1 Complex Provides Insights for the Role of Cortisol, hGR, and HPA Axis in Stress Management and Sleep Disorders.

Authors:  Sofia Raftopoulou; Nicolas C Nicolaides; Louis Papageorgiou; Anastasia Amfilochiou; Spyros G Zakinthinos; Potamitis George; Elias Eliopoulos; George P Chrousos; Dimitrios Vlachakis
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

Review 4.  Olive Oil Polyphenols in Neurodegenerative Pathologies.

Authors:  Constantinos Salis; Louis Papageorgiou; Eleni Papakonstantinou; Marianna Hagidimitriou; Dimitrios Vlachakis
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

5.  A holistic evolutionary and structural study of flaviviridae provides insights into the function and inhibition of HCV helicase.

Authors:  Dimitrios Vlachakis; Vassiliki Lila Koumandou; Sophia Kossida
Journal:  PeerJ       Date:  2013-05-07       Impact factor: 2.984
  5 in total

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