BACKGROUND: The aim of this study was to evaluate the relations of SDF-1 and its receptor, CXCR4, gene variants on oral cancer risk. METHODS: PCR-RFLP was used to measure SDF-1-3'A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. RESULTS: After being adjusted for age, individuals with A/G heterozygotes of SDF-1 had a higher risk of 1.86-fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66-fold to progress to stage III or IV. CONCLUSIONS: SDF-1-3'A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese. (c) 2009 Wiley Periodicals, Inc.
BACKGROUND: The aim of this study was to evaluate the relations of SDF-1 and its receptor, CXCR4, gene variants on oral cancer risk. METHODS: PCR-RFLP was used to measure SDF-1-3'A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. RESULTS: After being adjusted for age, individuals with A/G heterozygotes of SDF-1 had a higher risk of 1.86-fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66-fold to progress to stage III or IV. CONCLUSIONS:SDF-1-3'A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese. (c) 2009 Wiley Periodicals, Inc.
Authors: S Matsusaka; S Cao; D L Hanna; Y Sunakawa; M Ueno; N Mizunuma; W Zhang; D Yang; Y Ning; S Stintzing; A Sebio; S Stremitzer; S Yamauchi; A Parekh; S Okazaki; M D Berger; R El-Khoueiry; A Mendez; W Ichikawa; F Loupakis; H-J Lenz Journal: Pharmacogenomics J Date: 2016-08-09 Impact factor: 3.550
Authors: Risala Hussain Allami; Claudine Graf; Ksenia Martchenko; Beatrice Voss; Marc Becker; Martin R Berger; Peter R Galle; Matthias Theobald; Thomas C Wehler; Carl C Schimanski Journal: Oncol Lett Date: 2016-01-25 Impact factor: 2.967