Literature DB >> 19373590

A new beta-chain variant: Hb stockholm [beta 7(A4)GluAsp] causes falsely low Hb A(1c).

Ann-Charlotte Bergman1, Soheir Beshara, Irene Byman, Raja Karim, Britta Landin.   

Abstract

A new beta-hemoglobin (Hb) variant, Hb Stockholm [beta7(A4)GluAsp], is described. The variant was characterized by mass spectrometry and DNA sequencing. The new variant is clinically silent but interferes with Hb A(1c) quantification using ion exchange chromatography, causing a falsely low Hb A(1c) level when using the Bio-Rad VARIANT II System.

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Year:  2009        PMID: 19373590     DOI: 10.1080/03630260902861956

Source DB:  PubMed          Journal:  Hemoglobin        ISSN: 0363-0269            Impact factor:   0.849


  1 in total

1.  Self-catalytic DNA depurination underlies human β-globin gene mutations at codon 6 that cause anemias and thalassemias.

Authors:  Juan R Alvarez-Dominguez; Olga Amosova; Jacques R Fresco
Journal:  J Biol Chem       Date:  2013-03-01       Impact factor: 5.157

  1 in total

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