[The modification of the mechanically loaded periodontium during orthodontically induced tooth movement with nonsteroidal anti-inflammatory agents in an animal experiment].

In a total of 123 female adult Wistar rats the first upper molar was moved by orthodontics for more than 28 days. This orthodontically stimulated tooth movement was influenced by local application of Cu-salicylate, Cu-indomethacin or epsilon-Aminocapronacid. The application of Cu-salicylate and Cu-indomethacin caused reduced tooth movement, a decrease in osteoclasts in the pressure region of the periodontium, and an increase of hydroxyproline in the desmodont. Generally, the local application of Cu-nonsteroidal antiphlogistics seems to stabilize the experimentally induced tooth movement.