UNLABELLED: Acute allograft rejection remains a major complication after liver transplantation. We report a semiquantitative imaging method of detecting acute allograft rejection with (18)F-FDG PET. METHODS: Syngeneic and allogeneic transplanted rats, with or without immunosuppressive treatment, were subjected to serial PET. Autoradiography of the liver was conducted in both the syngeneic and the allogeneic rats. RESULTS: A significant increment of (18)F-FDG accumulation in liver allografts was observed by PET on day 2. The (18)F-FDG signal was concentrated in the area where inflammatory cells around the vessels were detected by autoradiography. Allotransplanted rats treated with an immunosuppressive agent displayed a marked decrease in hepatic (18)F-FDG uptake, compared with allotransplanted rats that were not treated. CONCLUSION: (18)F-FDG PET may be a valid method for facilitating the development of protocols to diagnose graft rejection and to monitor the efficacy of immunosuppressive therapy.
UNLABELLED: Acute allograft rejection remains a major complication after liver transplantation. We report a semiquantitative imaging method of detecting acute allograft rejection with (18)F-FDG PET. METHODS: Syngeneic and allogeneic transplanted rats, with or without immunosuppressive treatment, were subjected to serial PET. Autoradiography of the liver was conducted in both the syngeneic and the allogeneic rats. RESULTS: A significant increment of (18)F-FDG accumulation in liver allografts was observed by PET on day 2. The (18)F-FDG signal was concentrated in the area where inflammatory cells around the vessels were detected by autoradiography. Allotransplanted rats treated with an immunosuppressive agent displayed a marked decrease in hepatic (18)F-FDG uptake, compared with allotransplanted rats that were not treated. CONCLUSION: (18)F-FDG PET may be a valid method for facilitating the development of protocols to diagnose graft rejection and to monitor the efficacy of immunosuppressive therapy.
Authors: Jessica R Salas; Bao Ying Chen; Alicia Wong; Donghui Cheng; John S Van Arnam; Owen N Witte; Peter M Clark Journal: J Nucl Med Date: 2018-04-26 Impact factor: 10.057
Authors: Michael P Lisanti; Ubaldo E Martinez-Outschoorn; Zhao Lin; Stephanos Pavlides; Diana Whitaker-Menezes; Richard G Pestell; Anthony Howell; Federica Sotgia Journal: Cell Cycle Date: 2011-08-01 Impact factor: 4.534
Authors: D L Chen; X Wang; S Yamamoto; D Carpenter; J T Engle; W Li; X Lin; D Kreisel; A S Krupnick; H J Huang; A E Gelman Journal: Am J Transplant Date: 2013-08-08 Impact factor: 8.086