OBJECTIVE: To determine the effects of 2 maternal injections with dexamethasone on the calculated oxygen and glucose deliveries to fetal cerebral and peripheral circulations during acute hypoxemia in sheep. STUDY DESIGN: Beginning at 124 days, ewes received 2 intramuscular injections of either dexamethasone (2 x 12 mg, n = 10) or saline solution (2 x 2 mL, n = 12) 24 hours apart. Hypoxemia (1 hour) was induced 32 hours after the first injection (H1) and 3 days after the second (H2). RESULTS: In saline solution-treated fetuses, glucose delivery was unchanged or increased in femoral and carotid circulations, respectively, during H1 and H2. In dexamethasone-treated fetuses, the increase in glucose delivery to the head tended to be greater during H1 and was significantly enhanced in dexamethasone- vs saline solution-treated fetuses during H2. CONCLUSION: Two maternal injections with dexamethasone significantly enhanced glucose delivery to the head during acute hypoxemia in the ovine fetus.
OBJECTIVE: To determine the effects of 2 maternal injections with dexamethasone on the calculated oxygen and glucose deliveries to fetal cerebral and peripheral circulations during acute hypoxemia in sheep. STUDY DESIGN: Beginning at 124 days, ewes received 2 intramuscular injections of either dexamethasone (2 x 12 mg, n = 10) or saline solution (2 x 2 mL, n = 12) 24 hours apart. Hypoxemia (1 hour) was induced 32 hours after the first injection (H1) and 3 days after the second (H2). RESULTS: In saline solution-treated fetuses, glucose delivery was unchanged or increased in femoral and carotid circulations, respectively, during H1 and H2. In dexamethasone-treated fetuses, the increase in glucose delivery to the head tended to be greater during H1 and was significantly enhanced in dexamethasone- vs saline solution-treated fetuses during H2. CONCLUSION: Two maternal injections with dexamethasone significantly enhanced glucose delivery to the head during acute hypoxemia in the ovine fetus.
Authors: Christopher A Lear; Miriam E Koome; Joanne O Davidson; Paul P Drury; Josine S Quaedackers; Robert Galinsky; Alistair J Gunn; Laura Bennet Journal: J Physiol Date: 2014-11-10 Impact factor: 5.182
Authors: B J Allison; K L Brain; Y Niu; A D Kane; E A Herrera; A S Thakor; K J Botting; C M Cross; N Itani; K L Skeffington; C Beck; D A Giussani Journal: J Physiol Date: 2016-03-01 Impact factor: 5.182
Authors: Juanita K Jellyman; Malgorzata S Martin-Gronert; Roselle L Cripps; Dino A Giussani; Susan E Ozanne; Qingwu W Shen; Min Du; Abigail L Fowden; Alison J Forhead Journal: PLoS One Date: 2012-12-26 Impact factor: 3.240