BACKGROUND: We propose a completely automated methodology to investigate the relationship between magnetic resonance image (MRI) features and changes in cognitive estimates, applied to the study of Mini-Mental State Examination (MMSE) changes in mild cognitive impairment (MCI). SUBJECTS: A reference group composed of 75 patients with clinically probable Alzheimer's Disease (AD) and 75 age-matched controls; and a study group composed of 49 MCI, 20 having progressed to clinically probable AD and 29 having remained stable after a 48 month follow-up. METHODS: We created a pathology-specific reference space using principal component analysis of MRI-based features (intensity, local volume changes) within the medial temporal lobe of T1-weighted baseline images for the reference group. We projected similar data from the study group and identified a restricted set of image features highly correlated with one-year change in MMSE, using a bootstrap sampling estimation. We used robust linear regression models to predict one-year MMSE changes from baseline MRI, baseline MMSE, age, gender, and years of education. RESULTS: All experiments were performed using a leave-one-out paradigm. We found multiple image-based features highly correlated with one-year MMSE changes (/r/>0.425). The model for all N=49 MCI subjects had a correlation of r=0.31 between actual and predicted one-year MMSE change values. A second model only for MCI subjects with MMSE loss larger than 1 U had a pairwise correlation r=0.80 with an adjusted coefficient of determination r(2)=0.61. FINDINGS: Our automated MRI-based technique revealed a strong relationship between baseline MRI features and one-year cognitive changes in a sub-group of MCI subjects. This technique should be generalized to other aspects of cognitive evaluation and to a wider scope of dementias.
BACKGROUND: We propose a completely automated methodology to investigate the relationship between magnetic resonance image (MRI) features and changes in cognitive estimates, applied to the study of Mini-Mental State Examination (MMSE) changes in mild cognitive impairment (MCI). SUBJECTS: A reference group composed of 75 patients with clinically probable Alzheimer's Disease (AD) and 75 age-matched controls; and a study group composed of 49 MCI, 20 having progressed to clinically probable AD and 29 having remained stable after a 48 month follow-up. METHODS: We created a pathology-specific reference space using principal component analysis of MRI-based features (intensity, local volume changes) within the medial temporal lobe of T1-weighted baseline images for the reference group. We projected similar data from the study group and identified a restricted set of image features highly correlated with one-year change in MMSE, using a bootstrap sampling estimation. We used robust linear regression models to predict one-year MMSE changes from baseline MRI, baseline MMSE, age, gender, and years of education. RESULTS: All experiments were performed using a leave-one-out paradigm. We found multiple image-based features highly correlated with one-year MMSE changes (/r/>0.425). The model for all N=49 MCI subjects had a correlation of r=0.31 between actual and predicted one-year MMSE change values. A second model only for MCI subjects with MMSE loss larger than 1 U had a pairwise correlation r=0.80 with an adjusted coefficient of determination r(2)=0.61. FINDINGS: Our automated MRI-based technique revealed a strong relationship between baseline MRI features and one-year cognitive changes in a sub-group of MCI subjects. This technique should be generalized to other aspects of cognitive evaluation and to a wider scope of dementias.
Authors: Magda Bucholc; Xuemei Ding; Haiying Wang; David H Glass; Hui Wang; Girijesh Prasad; Liam P Maguire; Anthony J Bjourson; Paula L McClean; Stephen Todd; David P Finn; KongFatt Wong-Lin Journal: Expert Syst Appl Date: 2019-04-10 Impact factor: 6.954
Authors: Jing Qian; Seyedmehdi Payabvash; André Kemmling; Michael H Lev; Lee H Schwamm; Rebecca A Betensky Journal: Biometrics Date: 2013-12-09 Impact factor: 2.571
Authors: Cynthia M Stonnington; Carlton Chu; Stefan Klöppel; Clifford R Jack; John Ashburner; Richard S J Frackowiak Journal: Neuroimage Date: 2010-03-25 Impact factor: 6.556
Authors: Claudia Plant; Stefan J Teipel; Annahita Oswald; Christian Böhm; Thomas Meindl; Janaina Mourao-Miranda; Arun W Bokde; Harald Hampel; Michael Ewers Journal: Neuroimage Date: 2009-12-02 Impact factor: 6.556