BACKGROUND: Hepatitis A virus (HAV) is the most common cause of hepatitis in childhood and an important public health problem. The objective of the present study was to determine the seroprevalence of hepatitis A and patient demographics in children between 1 and 15 years old who were admitted to a pediatric outpatient clinic in Ankara, Turkey. METHODS: Hepatitis IgM and G antibodies were determined in the sera of children who attended the outpatient clinic. Informed consent was obtained from all subjects or their parents. RESULTS: The mean age of the children (n = 335) was 7.9 +/- 2.1 years; 47.5% of them were girls. The overall anti-HAV IgG prevalence in children aged 1-15 years was 47.2%. The positivity of hepatitis A IgM was highest in the 6-10 years age group (22.7%; P < 0.001). HAV IgG was highest in the 11-15 years age group (69.4%; P < 0.001). A total of 95.6% of the children had social insurance, 49.3% were living in poverty. The socioeconomic level of 82.4% of subjects was low. The history of hepatitis in their families was 6.9%. CONCLUSIONS: Hepatitis A is intermediate endemic in Ankara and children must be vaccinated before school age, in addition to health education and improved sanitation.
BACKGROUND:Hepatitis A virus (HAV) is the most common cause of hepatitis in childhood and an important public health problem. The objective of the present study was to determine the seroprevalence of hepatitis A and patient demographics in children between 1 and 15 years old who were admitted to a pediatric outpatient clinic in Ankara, Turkey. METHODS:Hepatitis IgM and G antibodies were determined in the sera of children who attended the outpatient clinic. Informed consent was obtained from all subjects or their parents. RESULTS: The mean age of the children (n = 335) was 7.9 +/- 2.1 years; 47.5% of them were girls. The overall anti-HAV IgG prevalence in children aged 1-15 years was 47.2%. The positivity of hepatitis A IgM was highest in the 6-10 years age group (22.7%; P < 0.001). HAV IgG was highest in the 11-15 years age group (69.4%; P < 0.001). A total of 95.6% of the children had social insurance, 49.3% were living in poverty. The socioeconomic level of 82.4% of subjects was low. The history of hepatitis in their families was 6.9%. CONCLUSIONS:Hepatitis A is intermediate endemic in Ankara and children must be vaccinated before school age, in addition to health education and improved sanitation.
Authors: Selim Badur; Serdar Öztürk; Alev Ozakay; Mansour Khalaf; Debasish Saha; Pierre Van Damme Journal: Hum Vaccin Immunother Date: 2021-07-02 Impact factor: 4.526