Literature DB >> 1936977

The effect of ketotifen on eosinophils as measured at LTC4 release and by chemotaxis.

M Nabe1, H Miyagawa, D K Agrawal, H Sugiyama, R G Townley.   

Abstract

We examined the effect of ketotifen on calcium ionophore (A23187)-induced leukotriene C4 (LTC4) release from eosinophils, and platelet activating factor (PAF)-induced eosinophil chemotaxis to estimate the mechanism of the antiasthmatic property of ketotifen. Purified eosinophil suspensions were obtained from eight atopic asthmatic subjects and eight normals. Twenty microM of ketotifen significantly inhibited A23187-induced LTC4 release from eosinophils, and 10 microM of ketotifen significantly inhibited PAF-induced eosinophil chemotaxis. These findings may demonstrate the antiallergic pharmacological properties of ketotifen.

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Year:  1991        PMID： 1936977     DOI： 10.2500/108854191778879313

Source DB:  PubMed          Journal:  Allergy Proc        ISSN： 1046-9354


  6 in total

Review 1.  Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis.

Authors:  Gyan P Mishra; Viral Tamboli; Jwala Jwala; Ashim K Mitra
Journal:  Recent Pat Inflamm Allergy Drug Discov       Date:  2011-01

Review 2.  Therapeutic Targets in Allergic Conjunctivitis.

Authors:  Bisant A Labib; DeGaulle I Chigbu
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-28

3.  Efficacy and safety of ketotifen eye drops in the treatment of seasonal allergic conjunctivitis.

Authors:  M Kidd; S H McKenzie; I Steven; C Cooper; R Lanz
Journal:  Br J Ophthalmol       Date:  2003-10       Impact factor: 4.638

4.  Onset and duration of action of ketotifen 0.025% and emedastine 0.05% in seasonal allergic conjunctivitis : efficacy after repeated pollen challenges in the vienna challenge chamber.

Authors:  Friedrich Horak; Petra Stübner; René Zieglmayer; Alexander Kawina; Michael Moser; René Lanz
Journal:  Clin Drug Investig       Date:  2003       Impact factor: 2.859

Review 5.  Allergic conjunctivitis: a comprehensive review of the literature.

Authors:  Mario La Rosa; Elena Lionetti; Michele Reibaldi; Andrea Russo; Antonio Longo; Salvatore Leonardi; Stefania Tomarchio; Teresio Avitabile; Alfredo Reibaldi
Journal:  Ital J Pediatr       Date:  2013-03-14       Impact factor: 2.638

6.  Survey on synergism effect of ketotifen in combination with pyrimethamine in treatment of acute murine toxoplasmosis.

Authors:  Mahbobeh Montazeri; Kian Rezaei; Mohammad Ali Ebrahimzadeh; Mehdi Sharif; Shahabeddin Sarvi; Ehsan Ahmadpour; Mohammad Taghi Rahimi; Abdol Satar Pagheh; Saeed Mehrzadi; Ahmad Daryani
Journal:  Trop Med Health       Date:  2017-11-21
  6 in total

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