Literature DB >> 19369077

Discovery of 4-azaindoles as novel inhibitors of c-Met kinase.

John Porter1, Simon Lumb, Richard J Franklin, Jose M Gascon-Simorte, Mark Calmiano, Kelly Le Riche, Bénédicte Lallemand, Jean Keyaerts, Helen Edwards, Alison Maloney, Jean Delgado, Lloyd King, Anne Foley, Fabien Lecomte, James Reuberson, Christoph Meier, Mark Batchelor.   

Abstract

A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed.

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Year:  2009        PMID： 19369077     DOI： 10.1016/j.bmcl.2009.03.110

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Pharmacophore modeling and virtual screening studies to identify new c-Met inhibitors.

Authors:  Wenting Tai; Tao Lu; Haoliang Yuan; Fengxiao Wang; Haichun Liu; Shuai Lu; Ying Leng; Weiwei Zhang; Yulei Jiang; Yadong Chen
Journal:  J Mol Model       Date:  2011-12-28       Impact factor: 1.810

2.  Structural basis for selective small molecule kinase inhibition of activated c-Met.

Authors:  Keith W Rickert; Sangita B Patel; Timothy J Allison; Noel J Byrne; Paul L Darke; Rachael E Ford; David J Guerin; Dawn L Hall; Maria Kornienko; Jun Lu; Sanjeev K Munshi; John C Reid; Jennifer M Shipman; Elizabeth F Stanton; Kevin J Wilson; Jonathon R Young; Stephen M Soisson; Kevin J Lumb
Journal:  J Biol Chem       Date:  2011-01-18       Impact factor: 5.157

3.  Docking and quantitative structure-activity relationship studies for 3-fluoro-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yloxy)aniline, 3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline, and 4-(4-amino-2-fluorophenoxy)-2-pyridinylamine derivatives as c-Met kinase inhibitors.

Authors:  Julio Caballero; Miguel Quiliano; Jans H Alzate-Morales; Mirko Zimic; Eric Deharo
Journal:  J Comput Aided Mol Des       Date:  2011-04-13       Impact factor: 3.686

4.  Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors.

Authors:  Tong-Chao Liu; Xia Peng; Yu-Chi Ma; Yin-Chun Ji; Dan-Qi Chen; Ming-Yue Zheng; Dong-Mei Zhao; Mao-Sheng Cheng; Mei-Yu Geng; Jing-Kang Shen; Jing Ai; Bing Xiong
Journal:  Acta Pharmacol Sin       Date:  2016-04-04       Impact factor: 6.150

5.  The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion.

Authors:  Mohamed S Mady; Mohamed M Mohyeldin; Hassan Y Ebrahim; Heba E Elsayed; Wael E Houssen; Eman G Haggag; Randa F Soliman; Khalid A El Sayed
Journal:  Bioorg Med Chem       Date:  2015-11-28       Impact factor: 3.641

6.  Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197.

Authors:  Sudharshan Eathiraj; Rocio Palma; Erika Volckova; Marscha Hirschi; Dennis S France; Mark A Ashwell; Thomas C K Chan
Journal:  J Biol Chem       Date:  2011-03-24       Impact factor: 5.157

7.  Simple Synthesis of a Heterocyclophane Exhibiting Anti-c-Met Activity by Acting as a Hatch Blocking Access to the Active Site*.

Authors:  Tatsuya Takimoto; Hideaki Sasaki; Hirohito Tsue; Hiroki Takahashi; Alexander D MacKerell; Ayumi Nakamura; Katsuya Nakano; Eori Okazaki; Tatsuki Betsuyaku; Ryosuke Tachibana; Kazuhito Hioki; Ozge Yoluk; Sunhwan Jo
Journal:  Chemistry       Date:  2020-12-15       Impact factor: 5.236

Review 8.  The azaindole framework in the design of kinase inhibitors.

Authors:  Jean-Yves Mérour; Frédéric Buron; Karen Plé; Pascal Bonnet; Sylvain Routier
Journal:  Molecules       Date:  2014-11-28       Impact factor: 4.411
  8 in total

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