Literature DB >> 19369036

Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model.

Julio Echegoyen1, Caren Armstrong, Robert J Morgan, Ivan Soltesz.   

Abstract

Effective prophylaxis for post-traumatic epilepsy currently does not exist, and clinical trials using anticonvulsant drugs have yielded no long-term antiepileptogenic effects. We report that a single, rapid post-traumatic application of the proconvulsant cannabinoid type-1 (CB1) receptor antagonist SR141716A (Rimonabant-Acomplia) abolishes the long-term increase in seizure susceptibility caused by head injury in rats. These results indicate that, paradoxically, a seizure-enhancing drug may disrupt the epileptogenic process if applied within a short therapeutic time window.

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Year:  2009        PMID： 19369036      PMCID： PMC2767525          DOI： 10.1016/j.eplepsyres.2009.02.019

Source DB:  PubMed          Journal:  Epilepsy Res        ISSN： 0920-1211            Impact factor:   3.045


  19 in total

1.  Opposing modifications in intrinsic currents and synaptic inputs in post-traumatic mossy cells: evidence for single-cell homeostasis in a hyperexcitable network.

Authors:  Allyson L Howard; Axel Neu; Robert J Morgan; Julio C Echegoyen; Ivan Soltesz
Journal:  J Neurophysiol       Date:  2006-08-30       Impact factor: 2.714

2.  Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures.

Authors:  Kang Chen; Axel Neu; Allyson L Howard; Csaba Földy; Julio Echegoyen; Lutz Hilgenberg; Martin Smith; Ken Mackie; Ivan Soltesz
Journal:  J Neurosci       Date:  2007-01-03       Impact factor: 6.167

3.  Soothing the seizures of children.

Authors:  Beat Lutz; Krisztina Monory
Journal:  Nat Med       Date:  2008-07       Impact factor: 53.440

4.  Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the 'irritable mossy cell' hypothesis.

Authors:  V Santhakumar; R Bender; M Frotscher; S T Ross; G S Hollrigel; Z Toth; I Soltesz
Journal:  J Physiol       Date:  2000-04-01       Impact factor: 5.182

5.  Brain injury-induced enhanced limbic epileptogenesis: anatomical and physiological parallels to an animal model of temporal lobe epilepsy.

Authors:  D A Coulter; A Rafiq; M Shumate; Q Z Gong; R J DeLorenzo; B G Lyeth
Journal:  Epilepsy Res       Date:  1996-12       Impact factor: 3.045

6.  Prevalence of epilepsy in Rochester, Minnesota: 1940-1980.

Authors:  W A Hauser; J F Annegers; L T Kurland
Journal:  Epilepsia       Date:  1991 Jul-Aug       Impact factor: 5.864

7.  Post-traumatic epilepsy following fluid percussion injury in the rat.

Authors:  Raimondo D'Ambrosio; Jared P Fairbanks; Jason S Fender; Donald E Born; Dana L Doyle; John W Miller
Journal:  Brain       Date:  2003-11-07       Impact factor: 13.501

8.  Posttraumatic epilepsy: a major problem in desperate need of major advances.

Authors:  Nina Garga; Daniel H Lowenstein
Journal:  Epilepsy Curr       Date:  2006 Jan-Feb       Impact factor: 7.500

Review 9.  Endocannabinoid signaling as a synaptic circuit breaker in neurological disease.

Authors:  István Katona; Tamás F Freund
Journal:  Nat Med       Date:  2008-09-05       Impact factor: 53.440

10.  The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy.

Authors:  Melisa J Wallace; Robert E Blair; Katherine W Falenski; Billy R Martin; Robert J DeLorenzo
Journal:  J Pharmacol Exp Ther       Date:  2003-09-03       Impact factor: 4.030
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  30 in total

1.  Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.

Authors:  Katherine W Sayers; Peter T Nguyen; Robert E Blair; Laura J Sim-Selley; Robert J DeLorenzo
Journal:  Epilepsia       Date:  2012-04-17       Impact factor: 5.864

Review 2.  Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research.

Authors:  Wolfgang Löscher; Claudia Brandt
Journal:  Pharmacol Rev       Date:  2010-12       Impact factor: 25.468

Review 3.  Control of excessive neural circuit excitability and prevention of epileptic seizures by endocannabinoid signaling.

Authors:  Yuki Sugaya; Masanobu Kano
Journal:  Cell Mol Life Sci       Date:  2018-05-08       Impact factor: 9.261

Review 4.  Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System.

Authors:  Shana M Augustin; David M Lovinger
Journal:  ACS Chem Neurosci       Date:  2018-02-19       Impact factor: 4.418

Review 5.  Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection.

Authors:  Evan C Rosenberg; Pabitra H Patra; Benjamin J Whalley
Journal:  Epilepsy Behav       Date:  2017-02-09       Impact factor: 2.937

6.  Traumatic Brain Injury Causes a Tacrolimus-Sensitive Increase in Non-Convulsive Seizures in a Rat Model of Post-Traumatic Epilepsy.

Authors:  John N Campbell; Anandh Gandhi; Baljinderjit Singh; Severn B Churn
Journal:  Int J Neurol Brain Disord       Date:  2014

7.  Toll-like Receptor 4 Signaling in Neurons Enhances Calcium-Permeable α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Currents and Drives Post-Traumatic Epileptogenesis.

Authors:  Akshata A Korgaonkar; Ying Li; Dipika Sekhar; Deepak Subramanian; Jenieve Guevarra; Bogumila Swietek; Alexandra Pallottie; Sukwinder Singh; Kruthi Kella; Stella Elkabes; Vijayalakshmi Santhakumar
Journal:  Ann Neurol       Date:  2020-02-24       Impact factor: 10.422

Review 8.  Epilepsy related to traumatic brain injury.

Authors:  Asla Pitkänen; Riikka Immonen
Journal:  Neurotherapeutics       Date:  2014-04       Impact factor: 7.620

Review 9.  Cannabinoids and Epilepsy.

Authors:  Evan C Rosenberg; Richard W Tsien; Benjamin J Whalley; Orrin Devinsky
Journal:  Neurotherapeutics       Date:  2015-10       Impact factor: 7.620

10.  Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi.

Authors:  Xian-Dong Meng; Dong Wei; Juan Li; Jun-Jun Kang; Chen Wu; Lei Ma; Feng Yang; Ge-Min Zhu; Tang-Peng Ou-Yang; Ying-Ying Liu; Wen Jiang
Journal:  Int J Clin Exp Pathol       Date:  2014-05-15
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