Literature DB >> 19368997

Inhibition of angiogenesis by extracellular protein kinase A.

Maria Szkudlarek1, Rual M Bosio, Qiong Wu, Khew-Voon Chin.   

Abstract

The cyclic-AMP dependent protein kinase (PKA) signaling pathway regulates cell growth, development, metabolism, and gene expression. Peripheral blood of cancer patients but not normal individuals, shows increased catalytic subunit levels of PKA (PKAc). We showed here that this extracellular form of PKAc (ECPKA) from conditioned media of cultured cancer cells as well as purified PKAc inhibit angiogenesis, using the in utero chicken embryo chorioallantoic membrane assay. Inhibition of angiogenesis is partially reversed by PKI, a peptide inhibitor of PKA, thus suggesting an anti-angiogenic role for ECPKA. The significance of ECPKA in cancer is discussed.

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Year:  2009        PMID： 19368997      PMCID： PMC2713806          DOI： 10.1016/j.canlet.2009.03.027

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  21 in total

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