BACKGROUND: The 9-repeat variable number tandem repeat allele of the dopamine transporter has recently been associated with borderline personality disorder (BPD) in depressed patients. METHODS: We investigated the association between the 9-repeat allele of the dopamine transporter and angry-impulsive personality traits in a family study with 512 subjects on the molecular genetics of depression and personality. RESULTS: Across the whole sample, the 9-repeat allele of the dopamine transporter was associated with angry-impulsive personality traits (p = .002). This association was stronger in subjects with no history of mood disorders or BPD (odds ratio [OR] = 4.85, p = .008) than in subjects with a history of mood disorders (OR = 1.73, p = .033). Angry-impulsive traits were also associated with lifetime mood disorder diagnoses and with BPD. CONCLUSIONS: The associations reported in this article suggest that the 9-repeat allele of the dopamine transporter is associated with angry-impulsive personality traits, independent of any link to mood disorder or BPD. This could form the basis of a dopaminergic neurobiological model of angry-impulsive personality traits.
BACKGROUND: The 9-repeat variable number tandem repeat allele of the dopamine transporter has recently been associated with borderline personality disorder (BPD) in depressedpatients. METHODS: We investigated the association between the 9-repeat allele of the dopamine transporter and angry-impulsive personality traits in a family study with 512 subjects on the molecular genetics of depression and personality. RESULTS: Across the whole sample, the 9-repeat allele of the dopamine transporter was associated with angry-impulsive personality traits (p = .002). This association was stronger in subjects with no history of mood disorders or BPD (odds ratio [OR] = 4.85, p = .008) than in subjects with a history of mood disorders (OR = 1.73, p = .033). Angry-impulsive traits were also associated with lifetime mood disorder diagnoses and with BPD. CONCLUSIONS: The associations reported in this article suggest that the 9-repeat allele of the dopamine transporter is associated with angry-impulsive personality traits, independent of any link to mood disorder or BPD. This could form the basis of a dopaminergic neurobiological model of angry-impulsive personality traits.
Authors: Victoria Kacprzak; Neil A Patel; Elizabeth Riley; Lili Yu; Jing-Ruey J Yeh; Irina V Zhdanova Journal: Pharmacol Biochem Behav Date: 2017-04-10 Impact factor: 3.533
Authors: Elizabeth P Hayden; Brigitte Hanna; Haroon I Sheikh; Rebecca S Laptook; Jiyon Kim; Shiva M Singh; Daniel N Klein Journal: Dev Psychopathol Date: 2013-02
Authors: Aaron J Stevens; Selma Stuffrein-Roberts; Simone L Cree; Andrew Gibb; Allison L Miller; Kit Doudney; Alan Aitchison; Michael R Eccles; Peter R Joyce; Vyacheslav V Filichev; Martin A Kennedy Journal: PLoS One Date: 2014-12-01 Impact factor: 3.240