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Literature DB >> 19367342

Polymorphism in Carbamazepine Cocrystals.

William W Porter¹, Sophia C Elie, Adam J Matzger.

Abstract

Cocrystals of carbamazepine with nicotinamide and saccharin are shown to be polymorphic. Two polymorphs of carbamazepine-nicotinamide (CBZ-NCT) cocrystals and two polymorphs of carbamazepine-saccharin (CBZ-SAC) cocrystals were grown from solution in the presence of polymer heteronuclei. The two CBZ-NCT polymorphs, CBZ-NCT I and a polymer nucleated (PN) form of CBZ-NCT, were characterized by Raman spectroscopy and powder X-ray diffraction. CBZ-SAC II, a new polymorph, was found to be in the monoclinic space group C2/c with a = 35.72 Å, b = 6.84 Å, c = 16.11 Å, and β = 98.03°. The unique feature of CBZ-SAC II is the formation of a heterosynthon between the carbamazepine and saccharin. These results are notable because CBZ-NCT and CBZ-SAC are among the most widely studied pharmaceutical cocrystals.

Entities: Chemical

Year: 2008 PMID： 19367342 PMCID： PMC2668533 DOI： 10.1021/cg701022e

Source DB: PubMed Journal: Cryst Growth Des ISSN： 1528-7483 Impact factor: 4.076

11 in total

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2. Polymer-induced heteronucleation for the discovery of new extended solids.

Authors: Adam L Grzesiak; Fernando J Uribe; Nathan W Ockwig; Omar M Yaghi; Adam J Matzger
Journal: Angew Chem Int Ed Engl Date: 2006-04-10 Impact factor: 15.336

3. Selection and discovery of polymorphs of platinum complexes facilitated by polymer-induced heteronucleation.

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Journal: Inorg Chem Date: 2007-01-22 Impact factor: 5.165

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Authors: Adivaraha Jayasankar; Anongnat Somwangthanaroj; Zezhi J Shao; Naír Rodríguez-Hornedo
Journal: Pharm Res Date: 2006-09-19 Impact factor: 4.200

5. Crystalline polymorph selection and discovery with polymer heteronuclei.

Authors: Christopher P Price; Adam L Grzesiak; Adam J Matzger
Journal: J Am Chem Soc Date: 2005-04-20 Impact factor: 15.419

Review 6. Pharmaceutical co-crystals.

Authors: Peddy Vishweshwar; Jennifer A McMahon; Joanna A Bis; Michael J Zaworotko
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Journal: Eur J Pharm Biopharm Date: 2006-12-28 Impact factor: 5.571

8. Crystallization pathways and kinetics of carbamazepine-nicotinamide cocrystals from the amorphous state by in situ thermomicroscopy, spectroscopy, and calorimetry studies.

Authors: K Seefeldt; J Miller; F Alvarez-Núñez; N Rodríguez-Hornedo
Journal: J Pharm Sci Date: 2007-05 Impact factor: 3.534

9. New form discovery for the analgesics flurbiprofen and sulindac facilitated by polymer-induced heteronucleation.

Authors: Adam L Grzesiak; Adam J Matzger
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Authors: Adam L Grzesiak; Meidong Lang; Kibum Kim; Adam J Matzger
Journal: J Pharm Sci Date: 2003-11 Impact factor: 3.534

14 in total

Review 1. Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development.

Authors: Dipak Dilip Gadade; Sanjay Sudhakar Pekamwar
Journal: Adv Pharm Bull Date: 2016-12-22

2. Investigating Cocrystallization of Carbamazepine with Structurally Compatible Coformers: New Cocrystal and Eutectic Phases with Enhanced Dissolution.

Authors: Indumathi Sathisaran; Sameer Vishvanath Dalvi
Journal: AAPS PharmSciTech Date: 2021-01-06 Impact factor: 3.246

Review 3. Engineering Cocrystals of PoorlyWater-Soluble Drugs to Enhance Dissolution in Aqueous Medium.

Authors: Indumathi Sathisaran; Sameer Vishvanath Dalvi
Journal: Pharmaceutics Date: 2018-07-31 Impact factor: 6.321

4. Physico-mechanical and stability evaluation of carbamazepine cocrystal with nicotinamide.

Authors: Ziyaur Rahman; Cyrus Agarabi; Ahmed S Zidan; Saeed R Khan; Mansoor A Khan
Journal: AAPS PharmSciTech Date: 2011-05-20 Impact factor: 3.246

5. On the mechanism of crystalline polymorph selection by polymer heteronuclei.

Authors: Vilmalí López-Mejías; Jennifer L Knight; Charles L Brooks; Adam J Matzger
Journal: Langmuir Date: 2011-05-19 Impact factor: 3.882

6. Peering at a buried polymer-crystal interface: probing heterogeneous nucleation by sum frequency generation vibrational spectroscopy.

Authors: Arthur A McClelland; Vilmalí López-Mejías; Adam J Matzger; Zhan Chen
Journal: Langmuir Date: 2011-02-15 Impact factor: 3.882