OBJECTIVE: We examined serotonin transporter (SERT) binding affinity using single photon emission computed tomography (SPECT) in patients with major depressive disorder (MDD) and night eating syndrome (NES). There are similarities between MDD and NES in affective symptoms, appetite disturbance, nighttime awakenings, and, particularly, response to selective serotonin reuptake inhibitors (SSRIs). METHODS: Six non-depressed patients with NES and seven patients with MDD underwent SPECT brain imaging with 123I-ADAM, a radiopharmaceutical agent selective for SERT sites. Uptake ratios of 123I-ADAM SERT binding were obtained for the midbrain, basal ganglia, and temporal lobe regions compared to the cerebellum reference region. RESULTS: Patients with NES had significantly greater SERT uptake ratios (effect size range 0.64-0.84) in the midbrain, right temporal lobe, and left temporal lobe regions than those with MDD whom we had previously studied. CONCLUSIONS: Pathophysiological differences in SERT uptake between patients with NES and MDD suggest these are distinct clinical syndromes.
OBJECTIVE: We examined serotonin transporter (SERT) binding affinity using single photon emission computed tomography (SPECT) in patients with major depressive disorder (MDD) and night eating syndrome (NES). There are similarities between MDD and NES in affective symptoms, appetite disturbance, nighttime awakenings, and, particularly, response to selective serotonin reuptake inhibitors (SSRIs). METHODS: Six non-depressedpatients with NES and seven patients with MDD underwent SPECT brain imaging with 123I-ADAM, a radiopharmaceutical agent selective for SERT sites. Uptake ratios of 123I-ADAM SERT binding were obtained for the midbrain, basal ganglia, and temporal lobe regions compared to the cerebellum reference region. RESULTS:Patients with NES had significantly greater SERT uptake ratios (effect size range 0.64-0.84) in the midbrain, right temporal lobe, and left temporal lobe regions than those with MDD whom we had previously studied. CONCLUSIONS: Pathophysiological differences in SERT uptake between patients with NES and MDD suggest these are distinct clinical syndromes.
Authors: John P O'Reardon; Kelly C Allison; Nicole S Martino; Jennifer D Lundgren; Moonseong Heo; Albert J Stunkard Journal: Am J Psychiatry Date: 2006-05 Impact factor: 18.112
Authors: John P O'Reardon; Brenda L Ringel; David F Dinges; Kelly Costello Allison; Naomi L Rogers; Nicole S Martino; Albert J Stunkard Journal: Obes Res Date: 2004-11
Authors: Albert J Stunkard; Kelly C Allison; Jennifer D Lundgren; Nicole S Martino; Moonseong Heo; Bijan Etemad; John P O'Reardon Journal: J Clin Psychiatry Date: 2006-10 Impact factor: 4.384
Authors: Jennifer D Lundgren; Andrew B Newberg; Kelly C Allison; Nancy A Wintering; Karl Ploessl; Albert J Stunkard Journal: Psychiatry Res Date: 2008-02-20 Impact factor: 3.222
Authors: Vibe G Frokjaer; Lars H Pinborg; Jacob Madsen; Robin de Nijs; Claus Svarer; Aase Wagner; Gitte M Knudsen Journal: J Nucl Med Date: 2008-01-16 Impact factor: 10.057
Authors: Fred W Turek; Corinne Joshu; Akira Kohsaka; Emily Lin; Ganka Ivanova; Erin McDearmon; Aaron Laposky; Sue Losee-Olson; Amy Easton; Dalan R Jensen; Robert H Eckel; Joseph S Takahashi; Joseph Bass Journal: Science Date: 2005-04-21 Impact factor: 47.728
Authors: Jay D Amsterdam; Andrew B Newberg; Cory F Newman; Justine Shults; Nancy Wintering; Irene Soeller Journal: J Neuroimaging Date: 2013-06-10 Impact factor: 2.486