Literature DB >> 19366260

Reversible self-assembly: a key feature for a new class of autodelivering therapeutic peptides.

Thelma A Pertinhez1, Stefania Conti, Elena Ferrari, Walter Magliani, Alberto Spisni, Luciano Polonelli.   

Abstract

Effective delivery is a critical issue in the use of conventional free drugs. Studies on the structure-function relationship of a therapeutic antibody-derived candidacidal decapeptide (killer peptide, KP) revealed its ability to spontaneously and reversibly self-assemble in an organized network of fibril-like structures. This process is catalyzed by 1,3-beta-glucans. While the self-assembled state may provide protection against proteases and the slow kinetic of dissociation assures a release of the active dimeric form over time, the beta-glucan affinity is responsible for targeted delivery. Thus, KP represents a novel paradigm of targeted autodelivering drugs.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19366260     DOI： 10.1021/mp900024z

Source DB:  PubMed          Journal:  Mol Pharm        ISSN： 1543-8384            Impact factor:   4.939


  9 in total

Review 1.  Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.

Authors:  Xuewen Du; Jie Zhou; Junfeng Shi; Bing Xu
Journal:  Chem Rev       Date:  2015-12-08       Impact factor: 60.622

2.  Dissecting the Structure-Function Relationship of a Fungicidal Peptide Derived from the Constant Region of Human Immunoglobulins.

Authors:  Tecla Ciociola; Thelma A Pertinhez; Laura Giovati; Martina Sperindè; Walter Magliani; Elena Ferrari; Rita Gatti; Tiziana D'Adda; Alberto Spisni; Stefania Conti; Luciano Polonelli
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

3.  Antibody complementarity-determining regions (CDRs): a bridge between adaptive and innate immunity.

Authors:  Elena Gabrielli; Eva Pericolini; Elio Cenci; Federica Ortelli; Walter Magliani; Tecla Ciociola; Francesco Bistoni; Stefania Conti; Anna Vecchiarelli; Luciano Polonelli
Journal:  PLoS One       Date:  2009-12-04       Impact factor: 3.240

4.  Peptides of the constant region of antibodies display fungicidal activity.

Authors:  Luciano Polonelli; Tecla Ciociola; Walter Magliani; Pier Paolo Zanello; Tiziana D'Adda; Serena Galati; Flavia De Bernardis; Silvia Arancia; Elena Gabrielli; Eva Pericolini; Anna Vecchiarelli; Denise C Arruda; Marcia R Pinto; Luiz R Travassos; Thelma A Pertinhez; Alberto Spisni; Stefania Conti
Journal:  PLoS One       Date:  2012-03-21       Impact factor: 3.240

5.  Nanomaterials: amyloids reflect their brighter side.

Authors:  Shruti Mankar; A Anoop; Shamik Sen; Samir K Maji
Journal:  Nano Rev       Date:  2011-05-31

6.  Antibody Peptide based antifungal immunotherapy.

Authors:  Walter Magliani; Stefania Conti; Laura Giovati; Pier Paolo Zanello; Martina Sperindè; Tecla Ciociola; Luciano Polonelli
Journal:  Front Microbiol       Date:  2012-06-01       Impact factor: 5.640

7.  Concentration- and pH-Dependent Oligomerization of the Thrombin-Derived C-Terminal Peptide TCP-25.

Authors:  Ganna Petruk; Jitka Petrlova; Firdaus Samsudin; Rita Del Giudice; Peter J Bond; Artur Schmidtchen
Journal:  Biomolecules       Date:  2020-11-19

Review 8.  Anti-Infective Antibody-Derived Peptides Active against Endogenous and Exogenous Fungi.

Authors:  Tecla Ciociola; Laura Giovati; Stefania Conti; Walter Magliani
Journal:  Microorganisms       Date:  2021-01-10

9.  In Vitro and In Vivo Anti-Candida Activity and Structural Analysis of Killer Peptide (KP)-Derivatives.

Authors:  Tecla Ciociola; Thelma A Pertinhez; Tiziano De Simone; Walter Magliani; Elena Ferrari; Silvana Belletti; Tiziana D'Adda; Stefania Conti; Laura Giovati
Journal:  J Fungi (Basel)       Date:  2021-02-10
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.