BACKGROUND: The role of human papillomavirus (HPV) in the pathogenesis of squamous cell carcinomas (SCCs) of the sinonasal tract and its clinicopathological implications were evaluated. METHODS: All SCCs of the sinonasal tract diagnosed in the Hospital Clinic of Barcelona from 1981 to 2006 were retrospectively evaluated (N = 60). Clinical and pathological data were reviewed. HPV infection was determined and typed by amplification of HPV DNA by polymerase chain reaction using the SPF-10 primers. p16(INK4a) expression was determined by immunohistochemistry. Overall and progression-free survival for HPV-positive and -negative patients was estimated by Kaplan-Meier analysis and by the use of a multivariate Cox proportional hazards model. RESULTS: HPV DNA was detected in tumor tissue of 12 of 60 (20%) patients. HPV16 was identified in 11 tumors and HPV35 in 1. Immunohistochemistry for p16(INK4a) stained all HPV-positive and no HPV-negative tumors (P < .001). No differences were observed in terms of site and histological grade or stage at presentation between HPV-positive and -negative tumors. However, HPV-positive patients had a significantly better 5-year progression-free survival (62%; 95% confidence interval [CI], 23%-86% vs 20%; 95% CI, 9%-34%; P = .0043, log-rank test) and overall survival (80%; 95% CI, 20%-96% vs 31%; 95% CI, 15%-47%; P = .036, log-rank test) than patients with HPV-negative tumors. In multivariate analysis, HPV-positive tumors were associated with improved progression-free survival (hazard ratio, 0.21; 95% CI, 0.17-0.98; P = .012). CONCLUSIONS: A subgroup of sinonasal SCCs is associated with HPV infection. These tumors have a significantly better prognosis. (c) 2009 American Cancer Society.
BACKGROUND: The role of human papillomavirus (HPV) in the pathogenesis of squamous cell carcinomas (SCCs) of the sinonasal tract and its clinicopathological implications were evaluated. METHODS: All SCCs of the sinonasal tract diagnosed in the Hospital Clinic of Barcelona from 1981 to 2006 were retrospectively evaluated (N = 60). Clinical and pathological data were reviewed. HPV infection was determined and typed by amplification of HPV DNA by polymerase chain reaction using the SPF-10 primers. p16(INK4a) expression was determined by immunohistochemistry. Overall and progression-free survival for HPV-positive and -negative patients was estimated by Kaplan-Meier analysis and by the use of a multivariate Cox proportional hazards model. RESULTS:HPV DNA was detected in tumor tissue of 12 of 60 (20%) patients. HPV16 was identified in 11 tumors and HPV35 in 1. Immunohistochemistry for p16(INK4a) stained all HPV-positive and no HPV-negative tumors (P < .001). No differences were observed in terms of site and histological grade or stage at presentation between HPV-positive and -negative tumors. However, HPV-positive patients had a significantly better 5-year progression-free survival (62%; 95% confidence interval [CI], 23%-86% vs 20%; 95% CI, 9%-34%; P = .0043, log-rank test) and overall survival (80%; 95% CI, 20%-96% vs 31%; 95% CI, 15%-47%; P = .036, log-rank test) than patients with HPV-negative tumors. In multivariate analysis, HPV-positive tumors were associated with improved progression-free survival (hazard ratio, 0.21; 95% CI, 0.17-0.98; P = .012). CONCLUSIONS: A subgroup of sinonasal SCCs is associated with HPV infection. These tumors have a significantly better prognosis. (c) 2009 American Cancer Society.
Authors: Ximena Mimica; Yao Yu; Marlena McGill; Christopher A Barker; Sean McBride; Ian Ganly; Jennifer R Cracchiolo; Lara A Dunn; Nora Katabi; Kevin Sine; Dennis Mah; Anna Lee; Nancy Lee; Marc A Cohen Journal: Head Neck Date: 2019-04-01 Impact factor: 3.147
Authors: James S Lewis; William H Westra; Lester D R Thompson; Leon Barnes; Antonio Cardesa; Jennifer L Hunt; Michelle D Williams; Pieter J Slootweg; Asterios Triantafyllou; Julia A Woolgar; Kenneth O Devaney; Alessandra Rinaldo; Alfio Ferlito Journal: Head Neck Pathol Date: 2013-12-14
Authors: Justin A Bishop; Simon Andreasen; Jen-Fan Hang; Martin J Bullock; Tiffany Y Chen; Alessandro Franchi; Joaquin J Garcia; Douglas R Gnepp; Carmen R Gomez-Fernandez; Stephan Ihrler; Ying-Ju Kuo; James S Lewis; Kelly R Magliocca; Stefan Pambuccian; Ann Sandison; Emmanuelle Uro-Coste; Edward Stelow; Katalin Kiss; William H Westra Journal: Am J Surg Pathol Date: 2017-12 Impact factor: 6.394
Authors: Justin A Bishop; Theresa W Guo; David F Smith; Hao Wang; Takenori Ogawa; Sara I Pai; William H Westra Journal: Am J Surg Pathol Date: 2013-02 Impact factor: 6.394
Authors: Justin A Bishop; Takenori Ogawa; Edward B Stelow; Christopher A Moskaluk; Wayne M Koch; Sara I Pai; William H Westra Journal: Am J Surg Pathol Date: 2013-06 Impact factor: 6.394