Literature DB >> 19365405

Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis.

Shih-Lei Lai1, Andy J Chien, Randall T Moon.   

Abstract

Wnt/beta-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. Beta-catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both beta-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.

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Year:  2009        PMID： 19365405     DOI： 10.1038/cr.2009.41

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  66 in total

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Review 4.  Pancreatic cancer stem cells.

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Journal:  Am J Cancer Res       Date:  2015-02-15       Impact factor: 6.166

5.  Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

Authors:  Leni S Jacob; Xiaofeng Wu; Michael E Dodge; Chih-Wei Fan; Ozlem Kulak; Baozhi Chen; Wei Tang; Baolin Wang; James F Amatruda; Lawrence Lum
Journal:  Sci Signal       Date:  2011-01-25       Impact factor: 8.192

6.  Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation.

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Journal:  J Biol Chem       Date:  2011-08-31       Impact factor: 5.157

7.  Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis.

Authors:  Mijung Kwon; Soo Jin Lee; Yarong Wang; Yevangelina Rybak; Alex Luna; Srilakshmi Reddy; Asha Adem; Brian T Beaty; John S Condeelis; Steven K Libutti
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Review 8.  The way Wnt works: components and mechanism.

Authors:  Kenyi Saito-Diaz; Tony W Chen; Xiaoxi Wang; Curtis A Thorne; Heather A Wallace; Andrea Page-McCaw; Ethan Lee
Journal:  Growth Factors       Date:  2012-12-21       Impact factor: 2.511

Review 9.  WNT signalling pathways as therapeutic targets in cancer.

Authors:  Jamie N Anastas; Randall T Moon
Journal:  Nat Rev Cancer       Date:  2013-01       Impact factor: 60.716

10.  2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes.

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Journal:  Inflamm Res       Date:  2015-11-27       Impact factor: 4.575
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