Literature DB >> 19364853

In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.

Victor Masseno1, Steven Muriithi, Alexis Nzila.   

Abstract

We tested the effect of probenecid and verapamil in chemosensitizing Plasmodium falciparum to 14 antimalarials using the multidrug-resistant strain V1S and the drug-sensitive 3D7. Verapamil chemosensitizes V1S to quinine and chloroquine. Interestingly, probenecid profoundly chemosensitizes V1S to piperaquine. Thus, probenecid could be used to increase piperaquine efficacy in vivo.

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Year:  2009        PMID： 19364853      PMCID： PMC2704629          DOI： 10.1128/AAC.01689-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  A method for testing for synergy with any number of agents.

Authors:  M C Berenbaum
Journal:  J Infect Dis       Date:  1978-02       Impact factor: 5.226

2.  Comparative efficacy of chloroquine plus chlorpheniramine alone and in a sequential combination with sulfadoxine-pyrimethamine, for the treatment of acute, uncomplicated, falciparum malaria in children.

Authors:  A Sowunmi; F A Fehintola; A A Adedeji; A G Falade; C O Falade; O O Akinyinka; A M Oduola
Journal:  Ann Trop Med Parasitol       Date:  2000-04

3.  In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum.

Authors:  Sheila Ommeh; Eunice Nduati; Eddy Mberu; Gilbert Kokwaro; Kevin Marsh; Andre Rosowsky; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

4.  Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents.

Authors:  David J Johnson; David A Fidock; Mathirut Mungthin; Viswanathan Lakshmanan; Amar Bir Singh Sidhu; Patrick G Bray; Stephen A Ward
Journal:  Mol Cell       Date:  2004-09-24       Impact factor: 17.970

5.  Open randomized study of pyrimethamine-sulphadoxine vs. pyrimethamine-sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children.

Authors:  A Sowunmi; F A Fehintola; A A Adedeji; G O Gbotosho; C O Falade; E Tambo; B A Fateye; T C Happi; A M J Oduola
Journal:  Trop Med Int Health       Date:  2004-05       Impact factor: 2.622

6.  Reversal of chloroquine resistance in Plasmodium falciparum by verapamil.

Authors:  S K Martin; A M Oduola; W K Milhous
Journal:  Science       Date:  1987-02-20       Impact factor: 47.728

7.  Reversal of mefloquine and quinine resistance in Plasmodium falciparum with NP30.

Authors:  Michelle Ciach; Kathleen Zong; Kevin C Kain; Ian Crandall
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

8.  A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites.

Authors:  Adele M Lehane; Rhys Hayward; Kevin J Saliba; Kiaran Kirk
Journal:  J Cell Sci       Date:  2008-04-29       Impact factor: 5.285

9.  Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.

Authors:  Amar Bir Singh Sidhu; Dominik Verdier-Pinard; David A Fidock
Journal:  Science       Date:  2002-10-04       Impact factor: 47.728

10.  Chemosensitization of Plasmodium falciparum by probenecid in vitro.

Authors:  Alexis Nzila; Eddy Mberu; Pat Bray; Gilbert Kokwaro; Peter Winstanley; Kevin Marsh; Steve Ward
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191
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  5 in total

1.  Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross.

Authors:  Jigar J Patel; Drew Thacker; John C Tan; Perri Pleeter; Lisa Checkley; Joseph M Gonzales; Bingbing Deng; Paul D Roepe; Roland A Cooper; Michael T Ferdig
Journal:  Mol Microbiol       Date:  2010-09-29       Impact factor: 3.501

2.  Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin.

Authors:  Vincent Delespaux; Hervé Sèna Vitouley; Tanguy Marcotty; Niko Speybroeck; Dirk Berkvens; Krisna Roy; Stanny Geerts; Peter Van den Bossche
Journal:  PLoS Negl Trop Dis       Date:  2010-09-28

3.  A kinetic fluorescence assay reveals unusual features of Ca⁺⁺ uptake in Plasmodium falciparum-infected erythrocytes.

Authors:  Elizabeth M Zipprer; McKinzie Neggers; Ambuj Kushwaha; Kempaiah Rayavara; Sanjay A Desai
Journal:  Malar J       Date:  2014-05-18       Impact factor: 2.979

4.  Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum.

Authors:  Juliana Quero Reimão; Juliana Tonini Mesquita; Daiane Dias Ferreira; Andre Gustavo Tempone
Journal:  Evid Based Complement Alternat Med       Date:  2016-01-28       Impact factor: 2.629

Review 5.  Innexins: Expression, Regulation, and Functions.

Authors:  Juan Güiza; Iván Barría; Juan C Sáez; José L Vega
Journal:  Front Physiol       Date:  2018-10-11       Impact factor: 4.566
  5 in total

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