Literature DB >> 19364648

A new synthesis of caged GABA compounds for studying GABAA receptors.

Lijun Fan1, Ryan W Lewis, George P Hess, Bruce Ganem.   

Abstract

A short and convergent synthetic approach to new photoactivatable precursors of gamma-aminobutyric acid (GABA) is described. When photolyzed, the 'caged' GABA precursor efficiently releases GABA, as judged by depolarization measurements on the mammalian GABA(A) receptor.

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Year:  2009        PMID: 19364648     DOI: 10.1016/j.bmcl.2009.03.065

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  7 in total

1.  Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

Authors:  Roy Weinstain; Tomáš Slanina; Dnyaneshwar Kand; Petr Klán
Journal:  Chem Rev       Date:  2020-10-30       Impact factor: 60.622

Review 2.  Applications of p-hydroxyphenacyl (pHP) and coumarin-4-ylmethyl photoremovable protecting groups.

Authors:  Richard S Givens; Marina Rubina; Jakob Wirz
Journal:  Photochem Photobiol Sci       Date:  2012-02-16       Impact factor: 3.982

Review 3.  Use of multicomponent reactions in developing small-molecule tools to study GABAA receptor mechanism and function.

Authors:  Ryan W Lewis; George P Hess; Bruce Ganem
Journal:  Future Med Chem       Date:  2011-02       Impact factor: 3.808

4.  Two-color, two-photon uncaging of glutamate and GABA.

Authors:  Srinivas Kantevari; Masanori Matsuzaki; Yuya Kanemoto; Haruo Kasai; Graham C R Ellis-Davies
Journal:  Nat Methods       Date:  2009-12-27       Impact factor: 28.547

Review 5.  Targeting drug delivery with light: A highly focused approach.

Authors:  Teresa L Rapp; Cole A DeForest
Journal:  Adv Drug Deliv Rev       Date:  2021-01-22       Impact factor: 15.470

Review 6.  Rational approaches for the design of various GABA modulators and their clinical progression.

Authors:  Kavita Bhagat; Jatinder V Singh; Piyusha P Pagare; Nitish Kumar; Anchal Sharma; Gurinder Kaur; Nihar Kinarivala; Srinivasa Gandu; Harbinder Singh; Sahil Sharma; Preet Mohinder S Bedi
Journal:  Mol Divers       Date:  2020-03-13       Impact factor: 2.943

7.  Fluorescence-based high-throughput functional profiling of ligand-gated ion channels at the level of single cells.

Authors:  Sahil Talwar; Joseph W Lynch; Daniel F Gilbert
Journal:  PLoS One       Date:  2013-03-08       Impact factor: 3.240

  7 in total

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