| Literature DB >> 19364643 |
David G Alberg1, Thomas B Poulsen, Søren Bertelsen, Kasper L Christensen, Rune D Birkler, Mogens Johannsen, Karl Anker Jørgensen.
Abstract
The aldol reaction of the endogeneous compounds acetone and methylglyoxal has been studied using organocatalysis in relation to biologically relevant non-enzymatic reactions. Under preparative conditions, 3-hydroxy-2,5-hexadione, known as Henze's ketol, is formed in high yield and with enantioselectivities up to 88% ee. Furthermore, Henze's ketol is also formed under simulated physiological conditions at micromolar scale, indicating that this reaction might take place in living organisms.Entities:
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Year: 2009 PMID： 19364643 DOI： 10.1016/j.bmcl.2009.03.128
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823