BACKGROUND: In the recent past large progress has been made in the analysis of the epigenome, the entirety of epigenetic modifications, and its meaning for the implementation of the genetic code. Besides histone modifications and miRNA expression, DNA methylation is one of the key players in the field of epigenetics, involved in numerous regulatory processes. METHODS: In the present review we focus on methods for the analysis of DNA methylation patterns and present an overview about techniques and basic principles available for this purpose. RESULTS AND GENERAL SIGNIFICANCE: We here discuss advantages and disadvantages of various methods and their feasibility for specific tasks of DNA methylation analysis.
BACKGROUND: In the recent past large progress has been made in the analysis of the epigenome, the entirety of epigenetic modifications, and its meaning for the implementation of the genetic code. Besides histone modifications and miRNA expression, DNA methylation is one of the key players in the field of epigenetics, involved in numerous regulatory processes. METHODS: In the present review we focus on methods for the analysis of DNA methylation patterns and present an overview about techniques and basic principles available for this purpose. RESULTS AND GENERAL SIGNIFICANCE: We here discuss advantages and disadvantages of various methods and their feasibility for specific tasks of DNA methylation analysis.
Authors: Priscilla Brebi-Mieville; Carmen Ili-Gangas; Pamela Leal-Rojas; Maartje G Noordhuis; Ethan Soudry; Jimena Perez; Juan Carlos Roa; David Sidransky; Rafael Guerrero-Preston Journal: Epigenetics Date: 2012-01-01 Impact factor: 4.528
Authors: Julia Richter; Ole Ammerpohl; José I Martín-Subero; Manuel Montesinos-Rongen; Marina Bibikova; Eliza Wickham-Garcia; Otmar D Wiestler; Martina Deckert; Reiner Siebert Journal: BMC Cancer Date: 2009-12-21 Impact factor: 4.430
Authors: Violetta V Leshchenko; Pei-Yu Kuo; Rita Shaknovich; David T Yang; Tobias Gellen; Adam Petrich; Yiting Yu; Yvonne Remache; Marc A Weniger; Sarwish Rafiq; K Stephen Suh; Andre Goy; Wyndham Wilson; Amit Verma; Ira Braunschweig; Natarajan Muthusamy; Brad S Kahl; John C Byrd; Adrian Wiestner; Ari Melnick; Samir Parekh Journal: Blood Date: 2010-04-28 Impact factor: 22.113
Authors: Susanne Bens; Andrea Haake; Julia Richter; Judith Leohold; Julia Kolarova; Inga Vater; Felix G Riepe; Karin Buiting; Thomas Eggermann; Gabriele Gillessen-Kaesbach; Konrad Platzer; Dirk Prawitt; Almuth Caliebe; Reiner Siebert Journal: Eur J Hum Genet Date: 2012-12-12 Impact factor: 4.246