BACKGROUND: Prospective studies of the effects of long-standing haemodialysis (HD) on quality of life (QOL) show conflicting results. We investigated how QOL progresses over time in HD patients and what factors are associated with this evolution. METHODS: We included chronic HD patients over the age of 18 from a single unit, who had never had transplants and survived the first 3 months of treatment. Ninety-two patients were followed for 2 years, and the SF-36 questionnaire was administered at baseline and every 12 months. Comorbidity was assessed at baseline using the Khan index. We used repeated-measures analysis of variance to establish changes in QOL and stepwise linear regression to identify continuous variables that could explain variations of SF-36 sub-scales. Then, according to the rate of change of QOL, we stratified the sample to identify the association between categorical variables and the evolution of QOL. RESULTS: There was a higher (better) final score related to social functioning (63.8 vs. 75.0; P < 0.01), role-emotional (39.7 vs. 63.1; P < 0.01) and mental health (63.1 vs. 69.0; P < 0.01) in the all-sample analysis, and in two other domains in low-comorbidity patients: physical functioning (56.7 vs. 63.5; P = 0.01) and bodily pain (56.7 vs. 66.5; P < 0.01). Creatinine (r = 0.09; P = 0.04) and age (r = -0.03; P = 0.02) were correlated with the evolution of general health and bodily pain, respectively. There were more women who presented deteriorated physical function than men (50.0 vs. 21.2%; P < 0.01). CONCLUSIONS: There was improvement of QOL mental domains over time. However, the physical aspects improved only in low-comorbidity patients. More women than men worsened regarding physical functioning.
BACKGROUND: Prospective studies of the effects of long-standing haemodialysis (HD) on quality of life (QOL) show conflicting results. We investigated how QOL progresses over time in HDpatients and what factors are associated with this evolution. METHODS: We included chronic HDpatients over the age of 18 from a single unit, who had never had transplants and survived the first 3 months of treatment. Ninety-two patients were followed for 2 years, and the SF-36 questionnaire was administered at baseline and every 12 months. Comorbidity was assessed at baseline using the Khan index. We used repeated-measures analysis of variance to establish changes in QOL and stepwise linear regression to identify continuous variables that could explain variations of SF-36 sub-scales. Then, according to the rate of change of QOL, we stratified the sample to identify the association between categorical variables and the evolution of QOL. RESULTS: There was a higher (better) final score related to social functioning (63.8 vs. 75.0; P < 0.01), role-emotional (39.7 vs. 63.1; P < 0.01) and mental health (63.1 vs. 69.0; P < 0.01) in the all-sample analysis, and in two other domains in low-comorbidity patients: physical functioning (56.7 vs. 63.5; P = 0.01) and bodily pain (56.7 vs. 66.5; P < 0.01). Creatinine (r = 0.09; P = 0.04) and age (r = -0.03; P = 0.02) were correlated with the evolution of general health and bodily pain, respectively. There were more women who presented deteriorated physical function than men (50.0 vs. 21.2%; P < 0.01). CONCLUSIONS: There was improvement of QOL mental domains over time. However, the physical aspects improved only in low-comorbidity patients. More women than men worsened regarding physical functioning.
Authors: I H Khan; M K Campbell; D Cantarovich; G R Catto; C Delcroix; N Edward; C Fontenaille; L W Fleming; P G Gerlag; H W van Hamersvelt; I S Henderson; R A Koene; M Papadimitriou; E Ritz; I T Russell; E Stier; D Tsakiris; A M MacLeod Journal: Nephrol Dial Transplant Date: 1996-02 Impact factor: 5.992
Authors: Albert W Wu; Nancy E Fink; Jane V R Marsh-Manzi; Klemens B Meyer; Frederic O Finkelstein; Michelle M Chapman; Neil R Powe Journal: J Am Soc Nephrol Date: 2004-03 Impact factor: 10.121
Authors: Antonio Alberto Lopes; Jennifer L Bragg-Gresham; David A Goodkin; Shunichi Fukuhara; Donna L Mapes; Eric W Young; Brenda W Gillespie; Tadao Akizawa; Roger N Greenwood; Vittorio E Andreucci; Takashi Akiba; Philip J Held; Friedrich K Port Journal: Qual Life Res Date: 2007-02-08 Impact factor: 4.147
Authors: B R Cassileth; E J Lusk; T B Strouse; D S Miller; L L Brown; P A Cross; A N Tenaglia Journal: N Engl J Med Date: 1984-08-23 Impact factor: 91.245
Authors: Eric Y F Wan; Julie Y Chen; Edmond P H Choi; Carlos K H Wong; Anca K C Chan; Karina H Y Chan; Cindy L K Lam Journal: Health Qual Life Outcomes Date: 2015-07-29 Impact factor: 3.186