| Literature DB >> 19362836 |
Roger J Gillespie1, Samantha J Bamford, Suneel Gaur, Allan M Jordan, Joanne Lerpiniere, Howard L Mansell, Gemma C Stratton.
Abstract
A novel series of antagonists of the human A(2A) receptor have been identified and have been shown to display good potency and high degrees of selectivity over other receptor sub-types. Displaying in vivo potency in commonly used disease models and high oral bio-availability, this class of compounds may serve as clinically useful treatments for the relief of the symptoms associated with Parkinson's disease.Entities:
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Year: 2009 PMID： 19362836 DOI： 10.1016/j.bmcl.2009.03.142
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823