PURPOSE: To evaluate the relationship between C-reactive protein (CRP) levels or the erythrocyte sedimentation rate (ESR) and the grade of acute radiation-induced mucositis in patients with head-and-neck cancer. METHODS AND MATERIALS: This study was performed in 40 patients who received intensity-modulated radiation therapy as a radical treatment of primary laryngo-pharyngeal cancer. Serum CRP level and ESR were initially checked on the day of radiotherapy simulation and were measured every week during the irradiation schedule and two times biweekly after radiotherapy. Mucosal reactions were evaluated by radiation oncologists on days of blood sampling. RESULTS: The distribution of the most severe mucositis was Grade I mucositis in 10% of the patients, Grade II in 60% of the patients and Grade III in 30% of the patients. Statistical analysis indicated a significant rise in the CRP level (p < 0.001) according to radiation fraction number and grade of mucositis. A change of the mean CRP level was correlated with progression of mean grade of mucositis according to fraction number. The ESR did not show any statistically significant relationship with radiotherapy fraction number and grade of acute mucositis. CONCLUSIONS: There was a significant correlation between the presence of acute mucositis and CRP level in this study. The CRP level could be conveniently determined along with evaluation of mucosal reactions during or after radiotherapy to provide further information on radiation-induced mucositis.
PURPOSE: To evaluate the relationship between C-reactive protein (CRP) levels or the erythrocyte sedimentation rate (ESR) and the grade of acute radiation-induced mucositis in patients with head-and-neck cancer. METHODS AND MATERIALS: This study was performed in 40 patients who received intensity-modulated radiation therapy as a radical treatment of primary laryngo-pharyngeal cancer. Serum CRP level and ESR were initially checked on the day of radiotherapy simulation and were measured every week during the irradiation schedule and two times biweekly after radiotherapy. Mucosal reactions were evaluated by radiation oncologists on days of blood sampling. RESULTS: The distribution of the most severe mucositis was Grade I mucositis in 10% of the patients, Grade II in 60% of the patients and Grade III in 30% of the patients. Statistical analysis indicated a significant rise in the CRP level (p < 0.001) according to radiation fraction number and grade of mucositis. A change of the mean CRP level was correlated with progression of mean grade of mucositis according to fraction number. The ESR did not show any statistically significant relationship with radiotherapy fraction number and grade of acute mucositis. CONCLUSIONS: There was a significant correlation between the presence of acute mucositis and CRP level in this study. The CRP level could be conveniently determined along with evaluation of mucosal reactions during or after radiotherapy to provide further information on radiation-induced mucositis.
Authors: Ana Gabriela Costa Normando; Camila Lopes Rocha; Isabela Porto de Toledo; Paulo Tadeu de Souza Figueiredo; Paula Elaine Diniz Dos Reis; Graziela De Luca Canto; Eliete Neves Silva Guerra Journal: Support Care Cancer Date: 2017-06-16 Impact factor: 3.603
Authors: Colleen E Krause; Brunah A Otieno; Gregory W Bishop; Gayatri Phadke; Linda Choquette; Rajesh V Lalla; Douglas E Peterson; James F Rusling Journal: Anal Bioanal Chem Date: 2015-07-05 Impact factor: 4.142
Authors: Christelle Machon; Simon Thezenas; Anne-Marie Dupuy; Eric Assenat; Françoise Michel; Emilie Mas; Pierre Senesse; Jean-Paul Cristol Journal: Support Care Cancer Date: 2012-03-28 Impact factor: 3.603
Authors: Harriët Jager-Wittenaar; Pieter U Dijkstra; Arjan Vissink; Rob P van Oort; Bernard F A M van der Laan; Jan L N Roodenburg Journal: Support Care Cancer Date: 2010-09-16 Impact factor: 3.603
Authors: Ylva Tiblom Ehrsson; Per M Hellström; Kerstin Brismar; Lena Sharp; Ann Langius-Eklöf; Göran Laurell Journal: Support Care Cancer Date: 2009-10-15 Impact factor: 3.603
Authors: Wojciech M Wysocki; Zofia Stasik; Zbigniew Darasz; Jerzy Jakubowicz; Jadwiga Tarapacz; Jan Kanty Kulpa Journal: Contemp Oncol (Pozn) Date: 2013-04-29